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Phase I study of camrelizumab in patients with advanced solid tumors.

作者信息

Ma Yuxiang, Cao Jiaxin, Zhang Yang, Liu Qianwen, Fang Wenfeng, Yang Yunpeng, Zhao Yuanyuan, Yang Qing, Zhao Hongyun, Zhang Li

机构信息

Department of Clinical Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, People's Republic of China.

Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, People's Republic of China.

出版信息

Signal Transduct Target Ther. 2023 Feb 1;8(1):47. doi: 10.1038/s41392-022-01213-6.

DOI:10.1038/s41392-022-01213-6
PMID:36725836
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9892498/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4823/9892498/3a73b3f1946b/41392_2022_1213_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4823/9892498/3a73b3f1946b/41392_2022_1213_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4823/9892498/3a73b3f1946b/41392_2022_1213_Fig1_HTML.jpg

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本文引用的文献

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CCR5 Receptor Occupancy Analysis Reveals Increased Peripheral Blood CCR5+CD4+ T Cells Following Treatment With the Anti-CCR5 Antibody Leronlimab.抗 CCR5 抗体 Leronlimab 治疗后外周血 CCR5+CD4+T 细胞增加的 CCR5 受体占有率分析。
Front Immunol. 2021 Nov 19;12:794638. doi: 10.3389/fimmu.2021.794638. eCollection 2021.
2
Effect of Camrelizumab vs Placebo Added to Chemotherapy on Survival and Progression-Free Survival in Patients With Advanced or Metastatic Esophageal Squamous Cell Carcinoma: The ESCORT-1st Randomized Clinical Trial.卡瑞利珠单抗联合化疗对比安慰剂用于治疗晚期或转移性食管鳞癌患者的生存和无进展生存期的影响:ESCORT-1 期随机临床试验。
JAMA. 2021 Sep 14;326(10):916-925. doi: 10.1001/jama.2021.12836.
3
A First-in-Human Dose Finding Study of Camrelizumab in Patients with Advanced or Metastatic Cancer in Australia.
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Drug Des Devel Ther. 2020 Mar 18;14:1177-1189. doi: 10.2147/DDDT.S243787. eCollection 2020.
4
Receptor occupancy measurement of anti-PD-1 antibody drugs in support of clinical trials.抗PD-1抗体药物的受体占有率测量以支持临床试验。
Bioanalysis. 2019 Jul;11(14):1347-1358. doi: 10.4155/bio-2019-0090. Epub 2019 Aug 8.
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Camrelizumab: First Global Approval.卡瑞利珠单抗:全球首次获批。
Drugs. 2019 Aug;79(12):1355-1361. doi: 10.1007/s40265-019-01167-0.