IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132, Milan, Italy.
Sci Rep. 2023 Feb 1;13(1):1822. doi: 10.1038/s41598-023-28906-4.
To compare clinical and imaging characteristics of extensive macular atrophy with pseudodrusen-like appearance (EMAP) versus diffuse-trickling geographic atrophy (DTGA) and non-diffuse-trickling geographic atrophy (nDTGA) phenotypes of age-related macular degeneration. Prospective, observational study performed in the Ophthalmology Department of IRCCS San Raffaele Hospital between January 2015 and January 2021. Patients examination included fundus autofluorescence (FAF) and optical coherence tomography at baseline and follow-up visits. We measured subfoveal choroidal thickness (SCT), Sattler/choroid ratio (SCR), choroidal vascularity index and ellipsoid zone disruption distance on OCT scans. We calculated progression rates and circularity of the atrophic lesions on FAF images. These variables were compared between the three groups and correlations with progression rates and visual acuity were assessed. Sixty-three eyes from 63 patients were included: 18 with EMAP, 18 with DTGA and 27 with nDTGA. Mean follow-up was 3.73 ± 2.12 years. EMAP and DTGA shared a faster progression, lower circularity and SCR, and higher EZ disruption distance than nDTGA, while SCT and CVI were similar between the three groups. Baseline circularity and SCR correlated with progression rates. EMAP and DTGA show similar OCT and FAF characteristics, which differ from nDTGA.
比较具有假性德鲁森样外观的广泛黄斑萎缩（EMAP）与年龄相关性黄斑变性的弥漫性滴状地理萎缩（DTGA）和非弥漫性滴状地理萎缩（nDTGA）表型的临床和影像学特征。这是一项在 2015 年 1 月至 2021 年 1 月期间在 IRCCS San Raffaele 医院眼科进行的前瞻性观察研究。患者检查包括眼底自发荧光（FAF）和光学相干断层扫描（OCT）基线和随访。我们测量了黄斑下脉络膜厚度（SCT）、Sattler/脉络膜比（SCR）、脉络膜血管指数和 OCT 扫描上的椭圆体带破坏距离。我们计算了 FAF 图像上萎缩病变的进展率和圆度。比较了三组之间的这些变量，并评估了与进展率和视力的相关性。纳入 63 名患者的 63 只眼：18 只眼为 EMAP，18 只眼为 DTGA，27 只眼为 nDTGA。平均随访时间为 3.73±2.12 年。EMAP 和 DTGA 的进展速度更快，圆度和 SCR 更低，EZ 破坏距离更高，而三组之间的 SCT 和 CVI 相似。基线圆度和 SCR 与进展率相关。EMAP 和 DTGA 具有相似的 OCT 和 FAF 特征，与 nDTGA 不同。
