Dennison A R, Collin J, Watkins R M, Millard P R, Morris P J
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, England.
Transplantation. 1987 Oct;44(4):474-8. doi: 10.1097/00007890-198710000-00003.
Fourteen dogs received an orthotopically vascularized allograft of a 100-cm length of terminal ileum as a Thiry-Vella segment. Absorption, motility, myoelectrical activity and morphology of the allograft were studied to determine the most reliable indices of rejection. The earliest histological evidence of rejection occurred at a mean of 6.2 +/- 0.9 days and was coincident with significant deterioration in the absorption of water, alanine, lauric acid, sodium, and glucose. Intestinal motility did not decrease until 7-8 days after transplantation, and intestinal myoelectrical activity was unchanged for a further 2-3 days, by which time graft necrosis was imminent. Reduced intestinal motility occurs only after rejection is established, and is therefore of little use as an index of rejection, while recording intestinal myoelectrical activity is valueless and serves only to confirm graft death. Decreased intestinal absorption of water, sodium, glucose, alanine, and lauric acid are present as early as the first changes in mucosal histology and are useful indices of rejection of intestinal allografts.
14只狗接受了一段100厘米长的终末回肠作为Thiry-Vella段的原位血管化同种异体移植。对同种异体移植的吸收、运动性、肌电活动和形态进行了研究，以确定最可靠的排斥指标。最早的排斥组织学证据平均出现在6.2±0.9天，同时水、丙氨酸、月桂酸、钠和葡萄糖的吸收显著恶化。肠道运动直到移植后7-8天才下降，肠道肌电活动在接下来的2-3天内没有变化，此时移植即将坏死。肠道运动减弱仅在排斥反应确立后才出现，因此作为排斥指标用处不大，而记录肠道肌电活动毫无价值，仅用于确认移植死亡。水、钠、葡萄糖、丙氨酸和月桂酸的肠道吸收减少早在黏膜组织学的最初变化时就出现了，是肠道同种异体移植排斥的有用指标。
