Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
J Cardiothorac Surg. 2023 Feb 1;18(1):52. doi: 10.1186/s13019-023-02150-3.
Thymic clear cell carcinoma is a rare mediastinal neoplasm, with only 25 reported cases to date. We report a case of a 45-year-old man with thymic clear cell carcinoma. We think imaging and laboratory tests may be helpful for differential diagnosis.
A 45-year-old male was admitted to a local hospital for chest distress with cardiopalmus. CT showed a mediastinal mass. Laboratory examination results were all in the normal range. Histologically, the tumor cells had a clear cytoplasm, and immunohistochemically, the tumor cells were positive for epithelial markers. We performed abdominal and pelvic CT and further examined serum levels of thyroxine, parathyroid hormone and AFP postoperatively, which were normal. The patient received postoperative radiotherapy, and CT showed left adrenal metastasis at 20 months after surgery.
Thymic clear cell carcinoma is a rare malignant neoplasm. Adrenal metastasis can occur. Patients undergo thymectomy with chemotherapy or with radiotherapy have better outcoming. Metastasis, direct invasion of parathyroid carcinoma and other primary tumors in the mediastinum should be excluded. Immunohistochemical markers, imaging and laboratory examination can help to exclude metastasis.
胸腺透明细胞癌是一种罕见的纵隔肿瘤，迄今为止仅有 25 例报道。我们报告了 1 例 45 岁男性胸腺透明细胞癌病例。我们认为影像学和实验室检查可能有助于鉴别诊断。
一名 45 岁男性因胸闷伴心悸入住当地医院。CT 显示纵隔肿块。实验室检查结果均在正常范围内。组织学上，肿瘤细胞具有透明细胞质，免疫组织化学染色显示肿瘤细胞上皮标志物阳性。我们进行了腹部和盆腔 CT 检查，并在术后进一步检查了甲状腺素、甲状旁腺激素和 AFP 的血清水平，均正常。患者接受了术后放疗，术后 20 个月 CT 显示左侧肾上腺转移。
胸腺透明细胞癌是一种罕见的恶性肿瘤。可发生肾上腺转移。行胸腺切除术联合化疗或放疗的患者预后较好。应排除转移、甲状旁腺癌直接侵犯和纵隔内其他原发性肿瘤。免疫组织化学标志物、影像学和实验室检查有助于排除转移。
