在胃癌中的表达促进预后并影响化疗。
The Expression of in Gastric Cancer Contributes to Prognosis and Influences Chemotherapy.
机构信息
Center for Systemic Inflammation Research (CSIR), School of Preclinical Medicine, Youjiang Medical University for Nationalities, Baise, Guangxi Province, China.
Department of Pediatric Surgery, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi Province, China.
出版信息
J Immunol Res. 2023 Jan 23;2023:2623317. doi: 10.1155/2023/2623317. eCollection 2023.
The altered expression of in patients with gastric cancer has been reported frequently, yet its correlation to prognosis and chemotherapy needs to be unveiled. In combination of the gene expression data retrieved from TCGA database and bioinformatic analysis, this study discovered 590 differentially expressed genes in the cancerous biopsies isolated from gastric patients, compared with controls. Among which, exhibited great potential to serve as a prognostic biomarker for gastric patients; furthermore, patients with low expression of could be more sensitive to these 9 chemotherapeutic agents: A-770041, AMG-706, ATRA, BEZ235, bortezomib, CGP60474, dasatinib, HG-64-1, and pazopanib, rather than the other chemotherapeutic agents. This study helps the improvement of evaluating the prognosis of gastric cancer patients, and would help optimize chemotherapeutic strategies in consideration of the expression of .
在胃癌患者中， 的表达改变经常被报道，但它与预后和化疗的相关性仍有待揭示。本研究结合从 TCGA 数据库中检索到的基因表达数据和生物信息学分析，发现与对照组相比，在胃癌患者的癌组织活检中存在 590 个差异表达基因。其中， 具有作为胃癌患者预后生物标志物的巨大潜力；此外，低表达 的患者对这 9 种化疗药物可能更敏感：A-770041、AMG-706、ATRA、BEZ235、硼替佐米、CGP60474、达沙替尼、HG-64-1 和帕唑帕尼，而不是其他化疗药物。本研究有助于改善对胃癌患者预后的评估，并有助于根据 的表达优化化疗策略。
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