Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Int J Public Health. 2023 Jan 16;68:1605332. doi: 10.3389/ijph.2023.1605332. eCollection 2023.
We investigated the associations of mean levels of leisure-time physical activity (LTPA) and latent LTPA trajectories with all-cause mortality risk. Trajectories of LTPA were established using group-based trajectory analysis with a latent class growth model in a population-based cohort between 1996 and 2014. A Cox-proportional hazard model was conducted to examine the associations of LTPA quintiles and LTPA trajectories with all-cause mortality. A total of 21,211 participants (age 18-90 years) were analyzed (median follow-up 16.8 years). The study participants were divided into five groups according to percentiles of LTPA (<20th, 20th-<40th, 40th-<60th, 60th-<80th, ≥80th) and LTPA trajectories (low/stable, medium/stable, increasing, decreasing, and fluctuating), respectively. Participants with a decreasing trajectory did not have a significantly lower risk of all-cause mortality despite having the highest baseline level of LTPA. In contrast, participants with a medium/stable (HR 0.84, 95% CI 0.72-0.98, = 0.031) or an increasing (HR 0.57, 95% CI 0.33-0.97, = 0.037) trajectory had a significantly lower risk of all-cause mortality. Promotion of maintaining stable LTPA is beneficial for public health and survival.
我们研究了休闲时间体力活动（LTPA）的平均水平和潜在 LTPA 轨迹与全因死亡率风险之间的关联。LTPA 轨迹是使用基于群组的轨迹分析和潜在类别增长模型在 1996 年至 2014 年期间的基于人群的队列中建立的。使用 Cox 比例风险模型来检验 LTPA 五分位数和 LTPA 轨迹与全因死亡率的相关性。共分析了 21211 名参与者（年龄 18-90 岁）（中位随访 16.8 年）。根据 LTPA（<20 岁、20-<40 岁、40-<60 岁、60-<80 岁、≥80 岁）和 LTPA 轨迹（低/稳定、中/稳定、增加、减少和波动）的百分位数，将研究参与者分为五组。尽管具有最高的基线 LTPA 水平，但具有下降轨迹的参与者的全因死亡率风险并没有显著降低。相比之下，具有中/稳定（HR 0.84，95%CI 0.72-0.98， = 0.031）或增加（HR 0.57，95%CI 0.33-0.97， = 0.037）轨迹的参与者的全因死亡率风险显著降低。促进保持稳定的 LTPA 对公共健康和生存有益。
