Department of Physical Education, Sport and Human Movement, Facultad de Formación de Profesorado y Educación, Universidad Autónoma de Madrid, Madrid, Spain.
IMDEA Food Institute, CEI UAM+CSIC, Madrid, Spain.
Br J Sports Med. 2020 Feb;54(4):238-244. doi: 10.1136/bjsports-2018-099740. Epub 2018 Dec 15.
We examined the dose-response relationship between physical activity (PA) and incidence of cardiovascular disease (CVD) risk factors in adults in Taiwan.
This study included 1 98 919 participants, aged 18-97 years, free of CVD, cancer and diabetes at baseline (1997-2013), who were followed until 2016. At baseline, participants were classified into five PA levels: inactive' (0 metabolic equivalent of task (MET)-h/week), 'lower insufficiently active' (0.1-3.75 MET-h/week), 'upper insufficiently active' (3.75-7.49 MET-h/week), 'active' (7.5-14.99 MET-h/week) and 'highly active' (≥15 MET-h/week]. CVD risk factors were assessed at baseline and at follow-up by physical examination and laboratory tests. Analyses were performed with Cox regression and adjusted for the main confounders.
During a mean follow-up of 6.0±4.5 years (range 0.5-19 years), 20 447 individuals developed obesity, 19 619 hypertension, 21 592 hypercholesterolaemia, 14 164 atherogenic dyslipidaemia, 24 275 metabolic syndrome and 8548 type 2 diabetes. Compared with inactive participants, those in the upper insufficiently active (but not active) category had a lower risk of obesity (HR 0.92; 95% CI 0.88 to 0.95), atherogenic dyslipidaemia (0.96; 0.90 to 0.99), metabolic syndrome (0.95; 0.92 to 0.99) and type 2 diabetes (0.91; 0.86 to 0.97). Only highly active individuals showed a lower incidence of CVD risk factors than their upper insufficiently active counterparts.
Compared with being inactive, doing half the recommended amount of PA is associated with a lower incidence of several common biological CVD risk factors. Given these benefits, half the recommended amount of PA is an evidence based target for inactive adults.
我们研究了身体活动（PA）与台湾成年人心血管疾病（CVD）风险因素发病率之间的剂量-反应关系。
本研究纳入了 198919 名年龄在 18-97 岁之间、基线时无 CVD、癌症和糖尿病的参与者（1997-2013 年），随访至 2016 年。基线时，参与者被分为五个 PA 水平：“不活动”（每周 0 代谢当量任务（MET）-h）、“低不活跃”（每周 0.1-3.75 MET-h）、“高不活跃”（每周 3.75-7.49 MET-h）、“活跃”（每周 7.5-14.99 MET-h）和“高活跃”（每周≥15 MET-h）。通过体检和实验室检查在基线和随访时评估 CVD 风险因素。使用 Cox 回归进行分析，并调整了主要混杂因素。
在平均 6.0±4.5 年（范围 0.5-19 年）的随访期间，20447 人发生肥胖，19619 人发生高血压，21592 人发生高胆固醇血症，14164 人发生动脉粥样硬化性血脂异常，24275 人发生代谢综合征，8548 人发生 2 型糖尿病。与不活动的参与者相比，上不活跃（但不活跃）组肥胖（HR 0.92；95%CI 0.88-0.95）、动脉粥样硬化性血脂异常（0.96；0.90-0.99）、代谢综合征（0.95；0.92-0.99）和 2 型糖尿病（0.91；0.86-0.97）的风险较低。只有高度活跃的个体发生 CVD 风险因素的发生率低于上不活跃的个体。
与不活动相比，进行推荐量的一半 PA 与几种常见的生物学 CVD 风险因素的发病率降低相关。鉴于这些益处，推荐量的一半 PA 是不活跃成年人的一个基于证据的目标。
