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1
Current therapies and new developments in NASH.非酒精性脂肪性肝炎的当前治疗方法与新进展
Gut. 2022 Jun 16;71(10):2123-34. doi: 10.1136/gutjnl-2021-326874.
2
Nonalcoholic Fatty Liver Disease and the Gut-Liver Axis: Exploring an Undernutrition Perspective.非酒精性脂肪性肝病与肠-肝轴：从营养不良角度进行探索
Gastroenterology. 2022 Jun;162(7):1858-1875.e2. doi: 10.1053/j.gastro.2022.01.058. Epub 2022 Mar 3.
3
Biodiversity of Gut Microbiota: Impact of Various Host and Environmental Factors.肠道微生物组的多样性：各种宿主和环境因素的影响。
Biomed Res Int. 2021 May 12;2021:5575245. doi: 10.1155/2021/5575245. eCollection 2021.
4
Effects of probiotic and prebiotic supplementation on metabolic parameters, liver aminotransferases, and systemic inflammation in nonalcoholic fatty liver disease: A randomized clinical trial.益生菌和益生元补充对非酒精性脂肪性肝病代谢参数、肝转氨酶和全身炎症的影响：一项随机临床试验。
J Food Sci. 2020 Oct;85(10):3611-3617. doi: 10.1111/1750-3841.15367. Epub 2020 Sep 4.
5
The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics.国际益生菌和益生元科学协会（ISAPP）关于共生元定义和范围的共识声明。
Nat Rev Gastroenterol Hepatol. 2020 Nov;17(11):687-701. doi: 10.1038/s41575-020-0344-2. Epub 2020 Aug 21.
6
Allogenic Fecal Microbiota Transplantation in Patients With Nonalcoholic Fatty Liver Disease Improves Abnormal Small Intestinal Permeability: A Randomized Control Trial.异体粪菌移植治疗非酒精性脂肪性肝病患者改善异常小肠通透性：一项随机对照试验。
Am J Gastroenterol. 2020 Jul;115(7):1055-1065. doi: 10.14309/ajg.0000000000000661.
7
Standardisation of diet and exercise in clinical trials of NAFLD-NASH: Recommendations from the Liver Forum.非酒精性脂肪性肝病-非酒精性脂肪性肝炎临床试验中饮食和运动的标准化：肝脏论坛的建议。
J Hepatol. 2020 Sep;73(3):680-693. doi: 10.1016/j.jhep.2020.04.030. Epub 2020 Apr 27.
8
Randomised Double-Blind Placebo-Controlled Trial of Inulin with Metronidazole in Non-Alcoholic Fatty Liver Disease (NAFLD).随机双盲安慰剂对照试验研究菊粉联合甲硝唑治疗非酒精性脂肪性肝病（NAFLD）。
Nutrients. 2020 Mar 27;12(4):937. doi: 10.3390/nu12040937.
9
Synbiotics Alter Fecal Microbiomes, But Not Liver Fat or Fibrosis, in a Randomized Trial of Patients With Nonalcoholic Fatty Liver Disease.共生元改变粪便微生物组，但不能改变非酒精性脂肪性肝病患者的肝脏脂肪或纤维化：一项随机试验。
Gastroenterology. 2020 May;158(6):1597-1610.e7. doi: 10.1053/j.gastro.2020.01.031. Epub 2020 Jan 25.
10
The gut-liver axis in liver disease: Pathophysiological basis for therapy.肝脏疾病中的肠-肝轴：治疗的病理生理学基础。
J Hepatol. 2020 Mar;72(3):558-577. doi: 10.1016/j.jhep.2019.10.003. Epub 2019 Oct 14.

肠道微生物群疗法治疗非酒精性脂肪性肝病：来自随机临床试验的证据。

Gut microbiota therapy for nonalcoholic fatty liver disease: Evidence from randomized clinical trials.

作者信息

Han Ting-Rui, Yang Wen-Juan, Tan Qing-Hua, Bai Shuai, Zhong Huang, Tai Yang, Tong Huan

机构信息

West China School of Medicine, Sichuan University, Chengdu, China.

Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.

出版信息

Front Microbiol. 2023 Jan 16;13:1004911. doi: 10.3389/fmicb.2022.1004911. eCollection 2022.

DOI:10.3389/fmicb.2022.1004911
PMID:36726574
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9884806/
Abstract

Nonalcoholic fatty liver disease (NAFLD) has a high prevalence worldwide, but there are no medications approved for treatment. Gut microbiota would be a novel and promising therapeutic target based on the concept of the gut-liver axis in liver disease. We reviewed randomized controlled trials on gut microbiota therapy in NAFLD in this study to evaluate its efficacy and plausibility in NAFLD.

摘要

非酒精性脂肪性肝病（NAFLD）在全球范围内具有很高的患病率，但目前尚无获批用于治疗的药物。基于肝病中肠-肝轴的概念，肠道微生物群将是一个新颖且有前景的治疗靶点。在本研究中，我们回顾了关于NAFLD肠道微生物群疗法的随机对照试验，以评估其在NAFLD中的疗效和合理性。