抗α4β7整合素抗体维多珠单抗治疗掌跖脓疱病的潜在疗效
Possible Efficacy of Vedolizumab, an Anti-α4β7 Integrin Antibody, in Palmoplantar Pustulosis.
作者信息
Terui Hitoshi, Moroi Rintaro, Masamune Atsushi, Aiba Setsuya, Yamasaki Kenshi
机构信息
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
出版信息
Case Rep Dermatol. 2023 Jan 27;15(1):22-25. doi: 10.1159/000529080. eCollection 2023 Jan-Apr.
Palmoplantar pustulosis (PPP) is a chronic skin inflammatory disease in which blisters and pustules repeatedly develop on palms and soles. PPP is often refractory to topical therapy, oral therapy, phototherapy, and biologics that are usually applied for PPP. We report a patient with PPP improved by vedolizumab (anti-α4β7 integrin antibody) treatment for ulcerative colitis, suggesting the possibility of a new molecular target for PPP therapy.
掌跖脓疱病（PPP）是一种慢性皮肤炎症性疾病，手掌和脚底反复出现水疱和脓疱。PPP通常对常用于治疗该病的局部治疗、口服治疗、光疗和生物制剂治疗效果不佳。我们报告了一名患有PPP的患者，其溃疡性结肠炎经维多珠单抗（抗α4β7整合素抗体）治疗后病情改善，这提示了PPP治疗新分子靶点的可能性。
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