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一名服用树莓酮减肥补充剂的患者出现耐药性多形性室性心动过速。

Resistant Polymorphic Ventricular Tachycardia in a Patient Taking Raspberry Ketones Weight Loss Supplement.

作者信息

Ansari Saad Ali, Patel Femina, Ashouri Diana, Dhaliwal Jasninder Singh S, Desai Aditya

机构信息

Internal Medicine, University of California Riverside School of Medicine, Riverside, USA.

出版信息

Cureus. 2022 Dec 29;14(12):e33089. doi: 10.7759/cureus.33089. eCollection 2022 Dec.

DOI:10.7759/cureus.33089
PMID:36726887
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9886374/
Abstract

A 32-year-old female with no cardiac risk factors was admitted for treatment of a perianal abscess. During her hospital stay, she had a pulseless electrical activity arrest with a return of spontaneous circulation after one round of cardiopulmonary resuscitation (CPR). After transfer to the Intensive Care Unit (ICU), the patient had polymorphic ventricular tachycardia (PVT) requiring defibrillation shock. Her PVT was resistant to medical interventions. She was shocked a total of 33 times before her arrhythmia was terminated by passing a temporary transvenous pacemaker with overdrive pacing. After an extensive review of her history and presentation, no clear cause of her resistant arrhythmia was identified, however, she was found to have recently started taking over-the-counter weight loss supplements containing raspberry ketones which is a potentially cardiotoxic ingredient.

摘要

一名无心脏危险因素的32岁女性因肛周脓肿入院治疗。在住院期间,她发生了无脉电活动心脏骤停,经过一轮心肺复苏后恢复了自主循环。转至重症监护病房(ICU)后,患者出现多形性室性心动过速(PVT),需要进行除颤电击。她的室性心动过速对药物干预无效。在通过临时经静脉起搏器进行超速起搏终止心律失常之前,她总共接受了33次电击。在对她的病史和临床表现进行全面检查后,未发现其难治性心律失常的明确原因,然而,发现她最近开始服用含有树莓酮的非处方减肥补充剂,而树莓酮是一种具有潜在心脏毒性的成分。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29dc/9886374/a536511d21bf/cureus-0014-00000033089-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29dc/9886374/8f3b7f10e2a8/cureus-0014-00000033089-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29dc/9886374/a536511d21bf/cureus-0014-00000033089-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29dc/9886374/8f3b7f10e2a8/cureus-0014-00000033089-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29dc/9886374/a536511d21bf/cureus-0014-00000033089-i02.jpg

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本文引用的文献

1
Coronary vasospasm and raspberry ketones weight-loss supplement: Is there a connection?冠状动脉痉挛与覆盆子酮减肥补充剂:存在关联吗?
Anatol J Cardiol. 2020 Sep;24(3):205-208. doi: 10.14744/AnatolJCardiol.2020.53496.
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The risky side of weight-loss dietary supplements: disrupting arrhythmias causing sudden cardiac arrest.减肥膳食补充剂的风险面:扰乱心律导致心脏骤停。
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Risks associated with fat burners: A toxicological perspective.脂肪燃烧剂的相关风险:毒理学视角。
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Raspberry ketone in food supplements--High intake, few toxicity data--A cause for safety concern?食品补充剂中的覆盆子酮——摄入量高,毒性数据少——是否引发安全担忧?
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Anti-obese action of raspberry ketone.树莓酮的抗肥胖作用。
Life Sci. 2005 May 27;77(2):194-204. doi: 10.1016/j.lfs.2004.12.029. Epub 2005 Feb 25.