Inayat Faisal, Majeed Chaudhry Nasir, Ali Nouman Safdar, Hayat Maham, Vasim Izzah
Allama Iqbal Medical College, Lahore, Pakistan.
Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA.
BMJ Case Rep. 2018 Dec 19;11(1):e227531. doi: 10.1136/bcr-2018-227531.
The worldwide increasing prevalence of obesity has led to a corresponding increase in consumption of weight-loss dietary supplements. The limited de novo regulatory oversight and under-reported toxicity profile of these products reflect as a constellation of newer adverse events. We chronicle here the case of an otherwise healthy woman who developed ventricular fibrillation-related cardiac arrest secondary to the use of Hydroxycut and Metaboost preparations. Published medical literature has a handful of case reports associating these products with potentially life-threatening cardiac arrhythmias. The proposed hypothesis implicates ingredients of these diet aids to have proarrhythmogenic effects. Physicians should remain vigilant for possible cardiotoxicity associated with the use of dietary supplements. Individuals who are at risk of developing cardiac arrhythmias should avoid herbal weight-loss formulas, given the serious clinical implications. Additionally, this paper highlights the need for a proper framework to delineate the magnitude and scope of this association.
全球肥胖患病率的不断上升导致减肥膳食补充剂的消费量相应增加。这些产品新出现的一系列不良事件反映出其监管监督有限且毒性报告不足。我们在此记录了一名原本健康的女性因服用Hydroxycut和Metaboost制剂而发生与心室颤动相关的心脏骤停的病例。已发表的医学文献中有少数病例报告将这些产品与潜在的危及生命的心律失常联系起来。提出的假设表明这些减肥辅助产品的成分具有促心律失常作用。医生应警惕与使用膳食补充剂相关的可能的心脏毒性。鉴于严重的临床影响，有发生心律失常风险的个体应避免使用草药减肥配方。此外，本文强调需要一个适当的框架来界定这种关联的程度和范围。
