呼吸道合胞病毒F抗原与人蛋白质组之间的分子模拟
Molecular Mimicry between Respiratory Syncytial Virus F Antigen and the Human Proteome.
作者信息
Kanduc Darja
机构信息
Department of Biosciences, Biotechnologies, and Biopharmaceutics, University of Bari, Bari, Italy.
出版信息
Glob Med Genet. 2023 Jan 30;10(1):19-21. doi: 10.1055/s-0043-1761489. eCollection 2023 Jan.
Abstract
This study examined respiratory syncytial virus (RSV) F glycoprotein (gp) antigen for molecular mimicry with the human proteome. It was found that the viral antigen presents an impressive number of pentapeptides (namely, 525 out of 570) in common with the human proteome, with viral sequences widely and repeatedly distributed among 3,762 human proteins implicated in crucial fundamental cellular functions. The data can have implications for anti-RSV vaccines. Indeed, the high level of molecular mimicry can lead to cross-reactivity and autoimmunity, and invites to follow safer vaccinal protocols based on pentapeptide sequences uniquely present in the viral antigen.
摘要
本研究检测了呼吸道合胞病毒（RSV）F糖蛋白（gp）抗原与人类蛋白质组的分子模拟情况。结果发现，该病毒抗原与人类蛋白质组有大量五肽相同（即在570个中占525个），病毒序列广泛且重复地分布在3762种参与关键基本细胞功能的人类蛋白质中。这些数据可能会对抗RSV疫苗产生影响。实际上，高度的分子模拟可能导致交叉反应和自身免疫，因此需要遵循基于病毒抗原中独特存在的五肽序列的更安全的疫苗接种方案。
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