From the Department of Neurology, TokyoMetropolitan Geriatric Hospital, Tokyo, Japan.
Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Clin Nucl Med. 2023 Apr 1;48(4):e204-e206. doi: 10.1097/RLU.0000000000004568. Epub 2023 Jan 20.
A 79-year-old man presenting with gait disturbance and cognitive decline was diagnosed with intravascular large B-cell lymphoma (IVLBCL) by random skin biopsy. Some IVLBCL lesions were identified by PET examinations using 11 C-methionine, 18 F-FDG, and 18 F-THK5351. 11 C-methionine and 18 F-FDG uptake, which likely reflects the presence of the lymphoma cells themselves, increased clearly in the left putamen but weakly in the left deep white matter. 18 F-THK5351 uptake increased in all lesions, likely reflecting perivascular astrogliosis caused by IVLBCL. Hence, 18 F-THK5351 PET can evaluate tumor extension in IVLBCL lesions where 11 C-methionine and 18 F-FDG PET may fail in its visualization.
一位 79 岁男性因步态障碍和认知能力下降就诊，经随机皮肤活检诊断为血管内大 B 细胞淋巴瘤（IVLBCL）。一些 IVLBCL 病变通过使用 11 C-蛋氨酸、18 F-FDG 和 18 F-THK5351 的 PET 检查得到识别。11 C-蛋氨酸和 18 F-FDG 摄取明显增加，可能反映了淋巴瘤细胞本身的存在，在左侧壳核中明显增加，但在左侧深部白质中较弱。18 F-THK5351 摄取在所有病变中均增加，可能反映了由 IVLBCL 引起的血管周围星形胶质增生。因此，18 F-THK5351 PET 可以评估 11 C-蛋氨酸和 18 F-FDG PET 可能无法显示的 IVLBCL 病变中的肿瘤扩展。
