Lee Christopher J, Nicoll Justin X
Department of Kinesiology, California State University, Northridge, Northridge, California.
J Strength Cond Res. 2023 Mar 1;37(3):710-725. doi: 10.1519/JSC.0000000000004409. Epub 2023 Jan 18.
Lee, CJ and Nicoll, JX. Time course evaluation of mitogen-activated protein kinase phosphorylation to resistance exercise: a systematic review. J Strength Cond Res 37(3): 710-725, 2023-Resistance exercise (RE) can increase the signaling activities of mitogen-activated protein kinases (MAPKs), specifically extracellular signal-regulated kinases 1/2 (ERK1/2), p90 ribosomal S6 kinases (p90RSK), c-Jun NH2-terminal kinases (JNK), and p38-MAPK. These RE-induced responses contribute to various intracellular processes modulating growth and development in skeletal muscles, playing an essential role in resistance training adaptations. The time course of MAPK phosphorylation to different RE conditions, such as training experience and varying loads, remains ambiguous. A systematic review was conducted to determine the effects of different post-RE recovery time points on the MAPK signaling cascade. In addition, the effects of loading and training statuses on MAPK responses were also investigated. The review was performed according to the preferred reporting items for systematic reviews and meta-analyses guidelines with a literature search incorporating 3 electronic databases. A modified version of the Downs and Black checklist was used to evaluate the methodological quality of the studies. The signaling responses were measured within a time range between immediately post-RE and >6 hours post-RE. Forty-four studies met the inclusion criteria, and all were classified as good-to-moderate methodological quality. Mitogen-activated protein kinase phosphorylation increased to different levels after RE, with the highest near the cessation of exercise. Although overall signaling was attenuated among trained individuals likely because of training adaptations, greater MAPK responses can be attributed to moderate loads of 65-85% 1RM regardless of the training experience. However, specific training-induced responses remain equivocal, and further investigations are required to determine the ideal training parameters to optimize anabolic intramuscular signaling, which may likely optimize resistance training adaptations.
李，CJ和尼科尔，JX。有丝分裂原活化蛋白激酶磷酸化对阻力训练的时间进程评估：一项系统综述。《力量与体能研究杂志》37(3): 710 - 725，2023年——阻力训练（RE）可增加有丝分裂原活化蛋白激酶（MAPKs）的信号传导活性，特别是细胞外信号调节激酶1/2（ERK1/2）、p90核糖体S6激酶（p90RSK）、c-Jun氨基末端激酶（JNK）和p38-MAPK。这些RE诱导的反应有助于调节骨骼肌生长和发育的各种细胞内过程，在阻力训练适应中发挥重要作用。MAPK磷酸化对不同RE条件（如训练经验和不同负荷）的时间进程仍不明确。进行了一项系统综述，以确定不同的RE后恢复时间点对MAPK信号级联反应的影响。此外，还研究了负荷和训练状态对MAPK反应的影响。该综述按照系统综述和Meta分析的首选报告项目指南进行，文献检索纳入了3个电子数据库。使用唐斯和布莱克清单的修改版来评估研究的方法学质量。信号反应在RE后立即至RE后>6小时的时间范围内进行测量。44项研究符合纳入标准，所有研究的方法学质量均被归类为良好至中等。有丝分裂原活化蛋白激酶磷酸化在RE后增加到不同水平，在运动停止时附近最高。尽管由于训练适应，训练有素的个体中的总体信号传导减弱，但无论训练经验如何，更大的MAPK反应可归因于65 - 85% 1RM的中等负荷。然而，特定训练诱导的反应仍然不明确，需要进一步研究以确定优化合成代谢肌内信号传导的理想训练参数，这可能会优化阻力训练适应。
