非剥脱性分次激光治疗与后续面部角质形成细胞癌发生风险降低相关。

Nonablative Fractional Laser Treatment Is Associated With a Decreased Risk of Subsequent Facial Keratinocyte Carcinoma Development.

作者信息

Benson Travis A, Hibler Brian P, Kotliar Dylan, Avram Mathew

机构信息

Harvard Medical School, Boston, Massachusetts; Schweiger Dermatology Group, New York, New York; Dermatology Laser and Cosmetics Center, Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts; and Broad Institute of MIT and Harvard, Cambridge, Massachusetts.

出版信息

Dermatol Surg. 2023 Feb 1;49(2):149-154. doi: 10.1097/DSS.0000000000003672. Epub 2022 Dec 6.

DOI:10.1097/DSS.0000000000003672

PMID:36728065

Abstract

BACKGROUND

Keratinocyte carcinoma (KC) is the most common type of nonmelanoma skin cancer. Currently, prophylactic treatment options are limited. Nonablative fractional lasers (NAFL) have received the Food and Drug Administration approval for the treatment of actinic damage; however, their role in KC prophylaxis is not known.

OBJECTIVE

The aim of this study is to determine whether NAFL treatment is associated with a decrease in subsequent facial KC development.

MATERIALS AND METHODS

A retrospective cohort study of patients with a history of facial KC treated at the Massachusetts General Hospital Dermatology Laser and Cosmetic Center between 2005 and 2021 was conducted.

RESULTS

Forty-three NAFL-treated patients with a history of facial KC and 52 matched control subjects were included in the study. The rate of subsequent facial KC development was 20.9% in NAFL-treated patients and 40.4% in control subjects (RR 0.52, p = .049). Control subjects developed new facial KC significantly sooner than NAFL-treated patients (p = .033). When controlling for age, gender, and skin type, control subjects were more likely to develop new facial KC than NAFL-treated patients (hazard ratio 2.65, p = .0169).

CONCLUSION

NAFL treatment was associated with a decreased risk of subsequent facial KC development and may have a benefit for KC prophylaxis.

摘要

背景

角质形成细胞癌（KC）是最常见的非黑色素瘤皮肤癌类型。目前，预防性治疗选择有限。非剥脱性分次激光（NAFL）已获得美国食品药品监督管理局批准用于治疗光化性损伤；然而，它们在KC预防中的作用尚不清楚。

目的

本研究的目的是确定NAFL治疗是否与随后面部KC发生的减少有关。

材料和方法

对2005年至2021年在马萨诸塞州总医院皮肤科激光与美容中心接受治疗的有面部KC病史的患者进行了一项回顾性队列研究。

结果

该研究纳入了43例有面部KC病史且接受过NAFL治疗的患者和52例匹配的对照受试者。接受NAFL治疗的患者随后面部KC发生的比率为20.9%，对照受试者为40.4%（相对危险度0.52，p = 0.049）。对照受试者出现新的面部KC明显早于接受NAFL治疗的患者（p = 0.033）。在控制年龄、性别和皮肤类型后，对照受试者比接受NAFL治疗的患者更有可能出现新的面部KC（风险比2.65，p = 0.0169）。