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Methyl CpG binding domain protein 2 (MBD2) in inflammation.

作者信息

Lei Qian, Zhang Wei

机构信息

Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, China.

Department of Critical Care Medicine, Kweichou Moutai Hospital, Renhuai, Guizhou 563000, China.

出版信息

Chin Med J (Engl). 2022 Dec 5;135(23):2880-2882. doi: 10.1097/CM9.0000000000002482.

DOI:10.1097/CM9.0000000000002482
PMID:36728519
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9945063/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/407f/9945063/45df0a73ba74/cm9-135-2880-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/407f/9945063/45df0a73ba74/cm9-135-2880-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/407f/9945063/45df0a73ba74/cm9-135-2880-g001.jpg

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Methyl CpG binding domain protein 2 (MBD2) in inflammation.炎症中的甲基化CpG结合域蛋白2（MBD2）
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2
Methyl-CpG-binding protein MBD2 plays a key role in maintenance and spread of DNA methylation at CpG islands and shores in cancer.甲基化CpG结合蛋白MBD2在癌症中CpG岛和海岸区域DNA甲基化的维持与扩散过程中发挥关键作用。
Oncogene. 2017 Mar;36(10):1328-1338. doi: 10.1038/onc.2016.297. Epub 2016 Sep 5.
3
Densely methylated DNA traps Methyl-CpG-binding domain protein 2 but permits free diffusion by Methyl-CpG-binding domain protein 3.高度甲基化的 DNA 可捕获甲基化 CpG 结合域蛋白 2，但允许甲基化 CpG 结合域蛋白 3 自由扩散。
J Biol Chem. 2022 Oct;298(10):102428. doi: 10.1016/j.jbc.2022.102428. Epub 2022 Aug 28.
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MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing.MBD3L2与MBD3及核小体重塑去乙酰化酶（NuRD）复合物的组分相互作用，并能对抗MBD2-MeCP1介导的甲基化沉默。
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CpG island promoter methylation and silencing of 14-3-3sigma gene expression in LNCaP and Tramp-C1 prostate cancer cell lines is associated with methyl-CpG-binding protein MBD2.LNCaP和Tramp - C1前列腺癌细胞系中14 - 3 - 3σ基因表达的CpG岛启动子甲基化和沉默与甲基化CpG结合蛋白MBD2相关。
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Preferential binding of the methyl-CpG binding domain protein 2 at methylated transcriptional start site regions.优先结合甲基化 CpG 结合域蛋白 2 于甲基化转录起始位点区域。
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Tagging methyl-CpG-binding domain proteins reveals different spatiotemporal expression and supports distinct functions.标记甲基化CpG结合域蛋白可揭示不同的时空表达并支持不同的功能。
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Methyl-CpG binding protein MBD2 is implicated in methylation-mediated suppression of miR-373 in hilar cholangiocarcinoma.甲基化 CpG 结合蛋白 MBD2 参与了肝门部胆管癌中甲基化介导的 miR-373 抑制。
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引用本文的文献

1
Exploring the bistable equilibrium of methylated CpG DNA recognition by the MBD2 protein.探索MBD2蛋白对甲基化CpG DNA识别的双稳态平衡。
bioRxiv. 2025 Jun 30:2025.06.30.662303. doi: 10.1101/2025.06.30.662303.

本文引用的文献

1
The methyl-CpG-binding domain 2 facilitates pulmonary fibrosis by orchestrating fibroblast to myofibroblast differentiation.甲基化 CpG 结合域 2 通过协调成纤维细胞向肌成纤维细胞分化来促进肺纤维化。
Eur Respir J. 2022 Sep 29;60(3). doi: 10.1183/13993003.03697-2020. Print 2022 Sep.
2
MBD2 acts as a repressor to maintain the homeostasis of the Th1 program in type 1 diabetes by regulating the STAT1-IFN-γ axis.MBD2 通过调节 STAT1-IFN-γ 轴作为一种抑制剂来维持 1 型糖尿病中 Th1 程序的内稳态。
Cell Death Differ. 2022 Jan;29(1):218-229. doi: 10.1038/s41418-021-00852-6. Epub 2021 Aug 21.
3
MBD2 Mediates Septic AKI through Activation of PKCη/p38MAPK and the ERK1/2 Axis.
MBD2通过激活PKCη/p38MAPK和ERK1/2轴介导脓毒症急性肾损伤。
Mol Ther Nucleic Acids. 2020 Sep 28;23:76-88. doi: 10.1016/j.omtn.2020.09.028. eCollection 2021 Mar 5.
4
MBD2 serves as a viable target against pulmonary fibrosis by inhibiting macrophage M2 program.MBD2 通过抑制巨噬细胞 M2 程序成为治疗肺纤维化的可行靶点。
Sci Adv. 2021 Jan 1;7(1). doi: 10.1126/sciadv.abb6075. Print 2021 Jan.
5
MBD2 regulates differentiation and function of Th17 cells in neutrophils- dominant asthma via HIF-1α.MBD2通过低氧诱导因子-1α调节中性粒细胞为主型哮喘中Th17细胞的分化和功能。
J Inflamm (Lond). 2018 Aug 20;15:15. doi: 10.1186/s12950-018-0191-x. eCollection 2018.
6
MBD2-mediated Th17 differentiation in severe asthma is associated with impaired SOCS3 expression.MBD2 介导的重症哮喘中的 Th17 分化与 SOCS3 表达受损有关。
Exp Cell Res. 2018 Oct 1;371(1):196-204. doi: 10.1016/j.yexcr.2018.08.010. Epub 2018 Aug 9.
7
Reduced MBD2 expression enhances airway inflammation in bronchial epithelium in COPD.MBD2表达降低会加重慢性阻塞性肺疾病支气管上皮的气道炎症。
Int J Chron Obstruct Pulmon Dis. 2018 Feb 28;13:703-715. doi: 10.2147/COPD.S148595. eCollection 2018.
8
MBD2 Regulates Th17 Cell Differentiation and Experimental Severe Asthma by Affecting IRF4 Expression.MBD2 通过影响 IRF4 表达调控 Th17 细胞分化和实验性重症哮喘。
Mediators Inflamm. 2017;2017:6249685. doi: 10.1155/2017/6249685. Epub 2017 Jul 20.
9
Methyl-CpG-binding domain proteins: readers of the epigenome.甲基化CpG结合域蛋白：表观基因组的读取器
Epigenomics. 2015;7(6):1051-73. doi: 10.2217/epi.15.39. Epub 2015 Apr 30.