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Circulating mitochondrial DNA levels are associated with early diagnosis and prognosis in patients with sepsis.

作者信息

Zhou Gaosheng, Liu Jingjing, Zhang Hongmin, Wang Xiaoting, Liu Dawei

机构信息

Department of Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuai Fu Yuan, Dongcheng District, Beijing 100730, China.

出版信息

Chin Med J (Engl). 2022 Dec 5;135(23):2883-2885. doi: 10.1097/CM9.0000000000002485.

DOI:10.1097/CM9.0000000000002485
PMID:36728529
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9943983/
Abstract
摘要

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Fatty acid synthesis promotes mtDNA release via ETS1-mediated oligomerization of VDAC1 facilitating endothelial dysfunction in sepsis-induced lung injury.脂肪酸合成通过ETS1介导的VDAC1寡聚促进线粒体DNA释放，从而加剧脓毒症诱导的肺损伤中的内皮功能障碍。
Cell Death Differ. 2025 May 14. doi: 10.1038/s41418-025-01524-5.

本文引用的文献

1
Plasma mitochondrial DNA levels are associated with acute lung injury and mortality in septic patients.血浆线粒体 DNA 水平与脓毒症患者急性肺损伤和死亡率相关。
BMC Pulm Med. 2021 Feb 25;21(1):66. doi: 10.1186/s12890-021-01437-2.
2
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).《脓毒症及脓毒性休克第三次国际共识定义（脓毒症-3）》
JAMA. 2016 Feb 23;315(8):801-10. doi: 10.1001/jama.2016.0287.
3
Mitochondrial DNA: An Endogenous Trigger for Immune Paralysis.线粒体 DNA：免疫瘫痪的内源性触发因素。
Anesthesiology. 2016 Apr;124(4):923-33. doi: 10.1097/ALN.0000000000001008.
4
Plasma Mitochondrial DNA--a Novel DAMP in Pediatric Sepsis.血浆线粒体DNA——小儿脓毒症中的一种新型损伤相关分子模式
Shock. 2016 May;45(5):506-11. doi: 10.1097/SHK.0000000000000539.
5
Plasma levels of mitochondrial DNA in patients presenting to the emergency department with sepsis.脓毒症患者就诊于急诊科时的血浆线粒体 DNA 水平。
Shock. 2012 Oct;38(4):337-40. doi: 10.1097/SHK.0b013e318266a169.
6
Plasma DNA concentration as a predictor of mortality and sepsis in critically ill patients.血浆DNA浓度作为危重症患者死亡率和脓毒症的预测指标
Crit Care. 2006;10(2):R60. doi: 10.1186/cc4894.
7
Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine.脓毒症与器官衰竭的定义以及脓毒症创新疗法的使用指南。ACCP/SCCM共识会议委员会。美国胸科医师学会/危重病医学会。
Chest. 1992 Jun;101(6):1644-55. doi: 10.1378/chest.101.6.1644.