地胆草地上部分中的新贝壳杉烷二萜。
ent-Pimarane Diterpenes from the Aerial Parts of Siegesbeckia pubescens.
机构信息
School of Biological Science and Technology, University of Jinan, Jinan, 250022, P. R. China.
Shandong Jincheng Pharmaceutical Group Co., Ltd., Zibo, 255100, P. R. China.
出版信息
Chem Biodivers. 2023 Mar;20(3):e202201090. doi: 10.1002/cbdv.202201090. Epub 2023 Feb 14.
Five new ent-pimarane diterpenes (1-5) and five known analogs (6-10) were isolated from the aerial parts of Siegesbeckia pubescens. Their structures, including absolute configurations, were determined by comprehensive spectroscopic methods especially 1D and 2D NMR and quantum chemical electronic circular dichroism calculations. All the isolated compounds were evaluated for their cytotoxicity against human BT549, A549 and H157 cancer cell lines. Among them, compounds 1 and 2 showed mild cytotoxicity against lung cancer cell lines H157 with IC values of 16.35±2.59 and 18.86±4.83 μM, respectively.
从飞扬草的地上部分分离得到了五个新的-ent-贝壳杉烷二萜（1-5）和五个已知类似物（6-10）。通过综合光谱方法，特别是 1D 和 2D NMR 和量子化学电子圆二色性计算，确定了它们的结构，包括绝对构型。所有分离得到的化合物都进行了细胞毒性评估，针对人 BT549、A549 和 H157 癌细胞系。其中，化合物 1 和 2 对肺癌细胞系 H157 表现出温和的细胞毒性，IC 值分别为 16.35±2.59 和 18.86±4.83 μM。
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