从 中分离得到的具有抗炎活性的新 -pimarane 型二萜。
A novel -pimarane-type diterpenoid from with anti-inflammatory activity.
机构信息
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
出版信息
J Asian Nat Prod Res. 2022 Mar;24(3):296-302. doi: 10.1080/10286020.2021.1915994. Epub 2021 Apr 19.
A novel -pimarane-type diterpenoid, sigesbeckia J (), along with two known diterpenoids, siegesbeckia acid () and -18-acetoxy-16,17-dihydroxykauran-19-oic acid (), were isolated from the aerial parts of Makino. Their chemical structures were elucidated based on extensive spectroscopic interpretation. The absolute configuration of -pimarane-type diterpenoid () was determined by comparing experimental and calculated ECD spectra. Compared with the positive control minocycline (IC 32.84 μM), compound exhibited moderate cell growth anti-inflammatory activities by testing their inhibition of LPS-induced NO production in BV2 microglial cells, with IC value of 58.74 μM.
从 Makino 的地上部分分离得到了一种新的 -pimarane 型二萜(sigesbeckia J ())，以及两种已知的二萜：siegesbeckia 酸 () 和 -18-乙酰氧基-16,17-二羟基贝壳杉-19-酸 ()。基于广泛的光谱解析，阐明了它们的化学结构。通过比较实验和计算的 ECD 光谱，确定了 -pimarane 型二萜 () 的绝对构型。与阳性对照米诺环素 (IC 32.84 μM) 相比，化合物 () 在 LPS 诱导的 BV2 小胶质细胞中 NO 产生的抑制作用测试中表现出中等的细胞生长抗炎活性，IC 值为 58.74 μM。
Zotero 插件