Bowles P M, Woolcock J B, Mutimer M D
Department of Veterinary Pathology and Public Health, University of Queensland, St. Lucia, Australia.
Vet Microbiol. 1987 Aug;14(3):259-68. doi: 10.1016/0378-1135(87)90113-1.
The growth kinetics in outbred mice of clinical and environmental isolates of Rhodococcus equi were followed by serial bacterial enumeration of organ homogenates. Clinical isolates multiplied until Day 4 before being progressively cleared, but could still be recovered from the liver at 3-4 weeks post-infection. Intravenous inoculation of clinical strains was associated with histopathological responses very similar to those elicited by intravenous infection with various facultative intracellular parasites. Whereas lesions in mice and foals at 7-9 days following respiratory infection are those of severe bronchopneumonia with massive consolidation, a week later the patterns of host response have diverged as the murine lesions resolve. The type strain, NCTC 1621 and 4-6 environmental isolates were eliminated without prior multiplication and these strains caused negligible lesions. The two environmental strains which behaved as the clinical strains were recovered from a stud with an R. equi problem. No association of colonial morphology of R. equi with virulence was apparent.
通过对器官匀浆进行连续细菌计数，跟踪了马红球菌临床分离株和环境分离株在远交系小鼠中的生长动力学。临床分离株在第4天前繁殖，随后逐渐被清除，但在感染后3 - 4周仍可从肝脏中分离出来。静脉接种临床菌株所引发的组织病理学反应与静脉感染各种兼性细胞内寄生虫所引发的反应非常相似。呼吸道感染后7 - 9天，小鼠和幼驹的病变为严重支气管肺炎并伴有大量实变，而一周后，随着小鼠病变的消退，宿主反应模式出现了分化。模式菌株NCTC 1621和4 - 6株环境分离株未经预先繁殖即被清除，这些菌株引起的病变可忽略不计。表现与临床菌株相同的两株环境菌株是从一个存在马红球菌问题的种马场中分离出来的。马红球菌的菌落形态与毒力之间没有明显关联。
