CD4 + T淋巴细胞缺陷转基因小鼠清除马红球菌感染的肺部功能失败。
Failure of pulmonary clearance of Rhodococcus equi infection in CD4+ T-lymphocyte-deficient transgenic mice.
作者信息
Kanaly S T, Hines S A, Palmer G H
机构信息
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164-7040.
出版信息
Infect Immun. 1993 Nov;61(11):4929-32. doi: 10.1128/iai.61.11.4929-4932.1993.
Abstract
Pulmonary clearance of Rhodococcus equi requires functional T lymphocytes. In this study, CD8+ T-lymphocyte-deficient transgenic mice cleared virulent R. equi from the lungs while infection in CD4+ T-lymphocyte-deficient transgenic mice persisted. Although both CD4+ and CD8+ T cells function early in pulmonary defense against R. equi, clearance is dependent on CD4+ T lymphocytes.
摘要
马红球菌的肺部清除需要功能性T淋巴细胞。在本研究中，CD8 + T淋巴细胞缺陷型转基因小鼠清除了肺部的强毒马红球菌，而CD4 + T淋巴细胞缺陷型转基因小鼠的感染持续存在。虽然CD4 +和CD8 + T细胞在肺部抵御马红球菌的早期均发挥作用，但清除依赖于CD4 + T淋巴细胞。
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