Kolev K K, Vŭrbanova S, Chervenkov S, Pavlov A
Vet Med Nauki. 1987;24(7):81-7.
Studied was the bacteriostatic activity of a total of 17 new esters and replaced 2-styryl derivatives of chlorquinaldol. Determined were also the lowest concentrations that suppressed the growth of organisms. Some of the compounds showed higher activity and broader spectrum of antibacterial qualities, mainly against Escherichia coli, Salmonella gallinarum, and Salmonella cholerae suis as compared to the initial therapeutic preparation chlorquinaldol. It was found that the presence of chlorine atoms either in the second or in the second and fourth place in the benzene nucleus of the esters studied, the presence of a NO2-group in the third place of the same nucleus, and the presence of an extranuclear hydroxyacetyl remainder in the ester grouping could lead to a rise of the antibacterial activity. The presence of an F atom in the second and third place of the benzene nucleus of the sterile grouping also raised the activity of these compounds.
研究了总共17种新的氯喹那多酯及其取代的2-苯乙烯基衍生物的抑菌活性。还测定了抑制微生物生长的最低浓度。与初始治疗制剂氯喹那多相比，一些化合物表现出更高的活性和更广泛的抗菌特性谱，主要针对大肠杆菌、鸡沙门氏菌和猪霍乱沙门氏菌。研究发现，在所研究酯的苯核的第二位或第二位和第四位存在氯原子、在同一核的第三位存在NO2基团以及在酯基团中存在核外羟基乙酰残基可导致抗菌活性提高。在无环基团的苯核的第二位和第三位存在F原子也提高了这些化合物的活性。
