镍催化的环烷基过氧化物的自由基开环膦酰化反应生成远程酰基膦氧化物。
Nickel-Catalyzed Radical Ring-Opening Phosphorylation of Cycloalkyl Hydroperoxides Leading to Distal Acylphosphine Oxides.
机构信息
Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, China.
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, Fujian, China.
出版信息
Org Lett. 2023 Feb 17;25(6):928-932. doi: 10.1021/acs.orglett.2c04233. Epub 2023 Feb 2.
A facile and efficient nickel-catalyzed C-C bond cleavage/phosphorylation of various cycloalkyl hydroperoxides was developed. This radical ring-opening strategy provided practical access to structurally diverse distal ketophosphine oxides in one pot through concurrent C═O/C-P bond formation with high atom economy under mild room temperature and base-free conditions.
发展了一种简便高效的镍催化的各种环烷基过氧化物的 C-C 键断裂/磷酸化反应。这种自由基开环策略通过在温和的室温条件下和无碱条件下同时形成 C═O/C-P 键，提供了一种从一锅反应中高原子经济性地获得结构多样的远程酮膦氧化物的实用方法。
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