铜催化炔基酸与次膦氧化物的串联膦化-脱羧-氧化反应：β-酮基膦氧化物的简便合成方法

Copper-catalyzed tandem phosphination-decarboxylation-oxidation of alkynyl acids with H-phosphine oxides: a facile synthesis of β-ketophosphine oxides.

作者信息

Zhang Pengbo, Zhang Liangliang, Gao Yuzhen, Xu Jian, Fang Hua, Tang Guo, Zhao Yufen

机构信息

Department of Chemistry, College of Chemistry and Chemical Engineering, and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005, China.

出版信息

Chem Commun (Camb). 2015 May 7;51(37):7839-42. doi: 10.1039/c5cc01904d.

DOI:10.1039/c5cc01904d

PMID:25855268

Abstract

The general method for the tandem phosphination-decarboxylation-oxidation of alkynyl acids under aerobic conditions has been developed. In the presence of CuSO4·5H2O and TBHP, the reactions provide a novel access to β-ketophosphine oxides in good to excellent yields. This transformation allows the direct formation of a P-C bond and the construction of a keto group in one reaction.

摘要

已开发出在有氧条件下对炔基酸进行串联磷化-脱羧-氧化的通用方法。在五水硫酸铜和叔丁基过氧化氢存在下，该反应能以良好至优异的产率提供一种制备β-酮基氧化膦的新方法。这种转化可在一个反应中直接形成P-C键并构建酮基。