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[弹状病毒科两种病毒对猴子的致病性比较特征]

[Comparative characteristics of the pathogenicity of 2 viruses of the family Rhabdoviridae for monkeys].

作者信息

Abramova L N, Terskikh I I, Gromashevskiĭ V L, L'vov D K

出版信息

Vopr Virusol. 1987 May-Jun;32(3):357-9.

PMID:3673026
Abstract

Pathogenic properties of two viruses, Sowgrass and Barur, of the Rhabdoviridae family, isolated in different geographical zones were studied comparatively in green monkeys. These viruses showed different pathogenicity for monkeys by the intracerebral and subcutaneous routes of inoculation. Sowgrass virus had no manifest pathogenicity for monkeys, whereas Barur virus caused death of the animals in 5-6 days after intracerebral inoculation with typical localization of lesions in the brain. Subcutaneous inoculation of the animals produced no fatalities; slight lesions in organs and production of virus-neutralizing antibodies in the blood were observed.

摘要

对从不同地理区域分离出的弹状病毒科的两种病毒——索格拉斯病毒和巴鲁病毒的致病特性,在绿猴身上进行了比较研究。通过脑内和皮下接种途径,这些病毒对猴子表现出不同的致病性。索格拉斯病毒对猴子无明显致病性,而巴鲁病毒在脑内接种后5 - 6天导致动物死亡,脑部有典型的损伤定位。对动物进行皮下接种未造成死亡;观察到器官有轻微损伤且血液中产生了病毒中和抗体。

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