Sokheĭ Ch, Obukhova V R
Vopr Virusol. 1984 May-Jun;29(3):290-4.
Pathogenicity and immunogenicity of Chandipura and Isfahan rhabdoviruses for laboratory animals were studied. Both viruses were found to be highly pathogenic for mice by the intracerebral route. Chandipura virus is highly pathogenic for mice of different ages by various routes of inoculation. The surviving animals were found to have antibodies demonstrable in different serological tests (agar gel diffusion and precipitation, complement-fixation, the neutralization test by plaque reduction in chick embryo cell culture). In the animals surviving the infection with Chandipura virus antibody could be found as early as 2 weeks, but after inoculation with Isfahan virus the antibody developed slowly and could be detected only at 4 weeks. Pathogenicity for mice of the T-227 and the prototype Isfahan virus strains differed slightly.
研究了钱迪普拉病毒和伊斯法罕弹状病毒对实验动物的致病性和免疫原性。通过脑内途径发现这两种病毒对小鼠均具有高度致病性。钱迪普拉病毒通过各种接种途径对不同年龄的小鼠均具有高度致病性。存活的动物在不同的血清学检测（琼脂凝胶扩散和沉淀、补体结合、鸡胚细胞培养中蚀斑减少中和试验）中被发现有可检测到的抗体。在用钱迪普拉病毒感染后存活的动物中，最早在2周时就能发现抗体，但在用伊斯法罕病毒接种后，抗体产生缓慢，仅在4周时才能检测到。T - 227株和原型伊斯法罕病毒株对小鼠的致病性略有不同。
