Department of Pathology, Cancer Institute.
Department of Pathology, Yas Hospital.
Appl Immunohistochem Mol Morphol. 2023 Feb 1;31(2):128-131. doi: 10.1097/PAI.0000000000001088. Epub 2022 Nov 21.
Cervical cancer is one of the most common genital cancers in the woman with approximately half a million new cases per year. Development of invasive squamous cell carcinoma (SCC) is the result of persistent and frequent human papilloma virus infection in premalignant lesions of cervix. Thereby identification of biomarkers that could predict progression of dysplastic mucosa to invasive cancer is of great clinical significance. Overexpression of SIRT1 has been reported to induce tumorogenesis in several organs. We evaluated SIRT1 expression in normal squamous epithelium of cervix, low-grade and high-grade cervical intraepithelial lesions and invasive SCC. A total of 104 cases were selected including 34 low-grade cervical intraepithelial lesions (CINs), 37 high-grade CINs, and 35 cases of invasive SCC. The normal cervical epithelium showed negative or weak SIRT1 positivity only in basal layers. SIRT1 cytoplasmic expression was found in 13 of 34 (38.2%) of low-grade CINs, 31 of 37 (83.8%) of high-grade CINs and all 35 (100%) cases of invasive SCC. Expression between 2 groups of CIN was statistically significant ( P =0.001). Thus, SIRT1 appears to be a promising biomarker for predicting the progression of CIN to invasive SCC.
宫颈癌是女性最常见的生殖系统癌症之一，每年约有 50 万例新发病例。浸润性鳞状细胞癌（SCC）的发展是宫颈前病变中持续性和频繁的人乳头瘤病毒感染的结果。因此，鉴定能够预测异型增生黏膜进展为浸润性癌的生物标志物具有重要的临床意义。SIRT1 的过表达已被报道在多个器官中诱导肿瘤发生。我们评估了 SIRT1 在宫颈正常鳞状上皮、低级别和高级别宫颈上皮内病变以及浸润性 SCC 中的表达。共选择了 104 例病例，包括 34 例低级别宫颈上皮内病变（CIN）、37 例高级别 CIN 和 35 例浸润性 SCC。正常宫颈上皮仅在基底层显示 SIRT1 弱阳性或阴性。在 34 例低级别 CIN 中的 13 例（38.2%）、37 例高级别 CIN 中的 31 例（83.8%）和所有 35 例（100%）浸润性 SCC 中发现了 SIRT1 细胞质表达。CIN 两组之间的表达具有统计学意义（P=0.001）。因此，SIRT1 似乎是预测 CIN 进展为浸润性 SCC 的有前途的生物标志物。
