Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China.
NHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Science Institute, Guangdong Provincial Fertility Hospital, Guangzhou, China.
Sci Total Environ. 2023 Apr 20;870:161892. doi: 10.1016/j.scitotenv.2023.161892. Epub 2023 Jan 31.
Accumulating evidence has linked exposure to ambient air pollution to a reduction in semen quality; however, the exposure-response associations are yet to be synthesized.
To summarize the exposure-response associations between air pollution and semen quality.
We systematically searched PubMed, Embase, and Web of Science for relevant studies published before April 20, 2022. Studies investigating the exposure-response association of PM, PM, SO, NO, CO, and O with semen quality written in English were included. Semen quality parameters included semen volume, sperm concentration, total sperm number, total motility, progressive motility, and normal forms. Random-effects and fixed-effects models were performed to synthesize associations in the meta-analysis.
The search returned 850 studies, 11 of which were eligible for meta-analysis. Each 10 μg/m increase of exposure to PM and SO was respectively associated with a 2.18 % (95 % confidence interval [CI]: 0.10 %-4.21 %) and 8.61 % (1.00 %-15.63 %) reduction in sperm concentration, and a 2.76 % (0.10 %-5.35 %) and 9.52 % (5.82 %-13.93 %) reduction in total sperm number. Each 10 μg/m increase of exposure to PM and PM was respectively associated with a 1.06 % (95 % CI: 0.31 %-1.82 %) and 0.75 % (0.43 %-1.08 %) reduction in total motility, and a 0.55 % (0.09 %-1.01 %) and 0.31 % (0.06 %-0.56 %) reduction in progressive motility. No association was observed for PM or PM with semen volume; PM, NO, CO, or O with sperm concentration or total sperm number; and gaseous air pollutants with total or progressive motility. The association between air pollution and normal forms was not summarized due to insufficient number of studies. No significant publication bias was detected.
Exposure to ambient PM, PM, and SO was inversely associated with sperm concentration, total sperm number, total motility, and/or progressive motility. Our findings add to the evidence that air pollution may lead to adverse effects on male reproductive system and suggest that reducing exposure to air pollution may help maintain better semen quality.
越来越多的证据表明，暴露于环境空气污染与精液质量下降有关；然而，暴露-反应关联尚未得到综合。
总结空气污染与精液质量之间的暴露-反应关联。
我们系统地检索了 PubMed、Embase 和 Web of Science，以获取截至 2022 年 4 月 20 日之前发表的相关研究。纳入了研究 PM、PM、SO、NO、CO 和 O 与精液质量的暴露-反应关系的英文研究。精液质量参数包括精液量、精子浓度、总精子数、总活力、前向运动精子活力和正常形态。在荟萃分析中，采用随机效应和固定效应模型来综合关联。
检索返回 850 项研究，其中 11 项符合荟萃分析条件。暴露于 PM 和 SO 每增加 10μg/m，精子浓度分别降低 2.18%（95%置信区间 [CI]：0.10%-4.21%）和 8.61%（1.00%-15.63%），总精子数分别降低 2.76%（0.10%-5.35%）和 9.52%（5.82%-13.93%）。暴露于 PM 和 PM 每增加 10μg/m，总活力分别降低 1.06%（95% CI：0.31%-1.82%）和 0.75%（0.43%-1.08%），前向运动精子活力分别降低 0.55%（0.09%-1.01%）和 0.31%（0.06%-0.56%）。PM 或 PM 与精液量、PM、NO、CO 或 O 与精子浓度或总精子数之间未观察到关联，气态空气污染物与总活力或前向运动精子活力之间也未观察到关联。由于研究数量不足，无法总结空气污染与正常形态之间的关联。未发现明显的发表偏倚。
暴露于环境 PM、PM 和 SO 与精子浓度、总精子数、总活力和/或前向运动精子活力呈负相关。我们的研究结果进一步证明，空气污染可能对男性生殖系统产生不良影响，并表明减少空气污染暴露可能有助于维持更好的精液质量。
