Wang Zeyuan, Zu Xiaoman, Xiong Shanshan, Mao Ren, Qiu Yun, Chen Baili, Zeng Zhirong, Chen Minhu, He Yao
Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.
Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Clin Ther. 2023 Feb;45(2):162-176. doi: 10.1016/j.clinthera.2023.01.004. Epub 2023 Feb 1.
Behcet disease (BD) is a multisystemic disorder characterized by variable clinical manifestations that affect nearly all systems and organs. Colchicine, an alkaloid plant extract, is considered as the first-line therapy for gout, pericarditis, and familial Mediterranean fever. However, the role of colchicine in the treatment of different clinical phenotypes of BD has not been clearly described. This narrative review summarizes the clinical use of colchicine in BD.
All relevant literature from 1980 to March 2021 was searched in PubMed, MEDLINE, and Cochrane Library. The Medical Subject Heading terms and related words that were searched are as follows: Behcet's disease, Behcet's syndrome, BD, colchicine, management, treatment, and therapy.
BD is an autoimmune systemic vasculitis with various clinical phenotypes, with involvement of skin mucosa, joints, eyes, and gastrointestinal, vascular, and neurologic systems. Colchicine has been used for centuries, acts by binding to tubulin to prevent the mitotic process, and has anti-inflammatory, antitumor, and antifibrotic properties. Colchicine has been reported to be an effective option for the treatment of skin, mucosal, and joint involvement in patients with certain BD clinical phenotypes.
Colchicine reduces the severity of certain clinical phenotypes and may improve the overall disease activity index in patients with BD. More randomized clinical trials are needed to confirm the value of colchicine in the treatment of BD, and further elucidation of the mechanisms is also needed, which may reveal new application of colchicine that has been used for centuries.
白塞病（BD）是一种多系统疾病，其临床表现多样，几乎累及所有系统和器官。秋水仙碱是一种生物碱植物提取物，被认为是痛风、心包炎和家族性地中海热的一线治疗药物。然而，秋水仙碱在治疗BD不同临床表型中的作用尚未得到明确描述。本叙述性综述总结了秋水仙碱在BD中的临床应用。
在PubMed、MEDLINE和Cochrane图书馆中检索了1980年至2021年3月的所有相关文献。检索的医学主题词及相关词汇如下：白塞病、白塞综合征、BD、秋水仙碱、管理、治疗和疗法。
BD是一种自身免疫性系统性血管炎，具有多种临床表型，累及皮肤黏膜、关节、眼睛以及胃肠道、血管和神经系统。秋水仙碱已使用数百年，通过与微管蛋白结合来阻止有丝分裂过程，具有抗炎、抗肿瘤和抗纤维化特性。据报道，秋水仙碱是治疗某些BD临床表型患者皮肤、黏膜和关节受累的有效选择。
秋水仙碱可减轻某些临床表型的严重程度，并可能改善BD患者的总体疾病活动指数。需要更多随机临床试验来证实秋水仙碱在BD治疗中的价值，还需要进一步阐明其机制，这可能揭示这种已使用数百年的药物的新用途。
