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高血压在小儿慢性肾脏病进展中的作用。

Role of hypertension in progression of pediatric CKD.

机构信息

Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA.

Division of Pediatric Nephrology, Center for Pediatrics and Adolescent Medicine, Heidelberg University Hospital, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.

出版信息

Pediatr Nephrol. 2023 Nov;38(11):3519-3528. doi: 10.1007/s00467-023-05894-1. Epub 2023 Feb 3.

DOI:10.1007/s00467-023-05894-1
PMID:36732375
Abstract

Hypertension is frequent in children with chronic kidney disease (CKD). Its prevalence varies according to CKD stage and cause. It is relatively uncommon in children with congenital kidney disease, while acquired kidney disease is associated with a higher prevalence of hypertension. Studies in children with CKD utilizing ambulatory blood pressure monitoring also showed a high prevalence of masked hypertension. Uncontrolled and longstanding hypertension in children is associated with progression of CKD. Aggressive treatment of high blood pressure should be an essential part of care to delay CKD progression in children.

摘要

高血压在慢性肾脏病(CKD)患儿中很常见。其患病率因 CKD 分期和病因而异。在先天性肾脏疾病患儿中相对少见,而获得性肾脏疾病与高血压患病率较高相关。利用动态血压监测的 CKD 患儿研究也显示出隐匿性高血压的高患病率。儿童高血压得不到控制和长期存在与 CKD 进展有关。积极治疗高血压应成为儿童延缓 CKD 进展的护理的重要组成部分。

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Kidney Int Rep. 2022 Aug 17;7(11):2446-2453. doi: 10.1016/j.ekir.2022.08.002. eCollection 2022 Nov.
2
Intensive compared with less intensive blood pressure control to prevent adverse cardiac remodelling in children with chronic kidney disease (HOT-KID): a parallel-group, open-label, multicentre, randomised, controlled trial.强化降压与轻度降压控制对预防慢性肾脏病儿童心脏重构不良的比较(HOT-KID):一项平行组、开放标签、多中心、随机、对照试验。
Lancet Child Adolesc Health. 2023 Jan;7(1):26-36. doi: 10.1016/S2352-4642(22)00302-9. Epub 2022 Nov 25.
3
Nocturnal Hypertension in Children With Chronic Kidney Disease Is Common and Associated With Progression to Kidney Replacement Therapy.
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Hypertension. 2022 Oct;79(10):2288-2297. doi: 10.1161/HYPERTENSIONAHA.121.18101. Epub 2022 Aug 18.
4
Altered dietary salt intake for people with chronic kidney disease.改变慢性肾脏病患者的饮食盐摄入量。
Cochrane Database Syst Rev. 2021 Jun 24;6(6):CD010070. doi: 10.1002/14651858.CD010070.pub3.
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Hypertension. 2021 Jul;78(1):65-73. doi: 10.1161/HYPERTENSIONAHA.120.16692. Epub 2021 Jun 1.
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