Department of Cardiovascular Surgery, National Center for Cardiovascular Diseases and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, No. 167, North Lishi Street, Xicheng District, Beijing, China.
Department of Cardiovascular Surgery, Yunnan Fuwai Cardiovascular Hospital, Kunming, China.
BMC Cardiovasc Disord. 2023 Feb 2;23(1):60. doi: 10.1186/s12872-023-03095-0.
Both bicuspid aortic valve (BAV) and bovine aortic arch (BA) are considered as markers of thoracic aortic disease (TAD). But the association between them is not yet clear. This study aimed to explore the potential association of BAV and BA with TAD.
The study involved 449 participants who underwent their first aortic valve replacement in Fuwai Hospital from June 2017 to March 2018. All patients underwent multidetector computed tomography and echocardiography before surgery. The clinical characteristics were recorded to analyze the association between BAV, BA, and TAD. The univariate and multivariate logistic regression analyses were applied to identify the risk factors for TAD.
BA accounted for 79.8% of the arch variants and was the most common aortic arch branching variant. BAV was present in 52.6% of the patients with BA and 38.1% of the patients with normal arch (NA). Among the 185 patients in the BAV subgroup, 50 had BA and 135 had NA. No significant differences were found in BAV anatomical phenotype, aortopathy phenotype, and valve function between BA and NA. The multivariate analysis showed that the presence of BAV and male sex were the risk predictors of TAD. BA was not a risk factor for TAD in either univariate or multivariate analysis.
The proportion of BAV in patients with BA was significantly higher than that of NA, but the BAV phenotype and aortopathy were not related to BA. BAV was a risk factor for TAD, whereas BA was not associated with TAD.
二叶式主动脉瓣（BAV）和牛型主动脉弓（BA）均被认为是胸主动脉疾病（TAD）的标志物。但两者之间的关联尚不清楚。本研究旨在探讨 BAV 和 BA 与 TAD 之间的潜在关联。
该研究纳入了 2017 年 6 月至 2018 年 3 月期间在阜外医院接受首次主动脉瓣置换术的 449 名患者。所有患者均在术前接受了多排螺旋 CT 和超声心动图检查。记录临床特征，以分析 BAV、BA 和 TAD 之间的关联。采用单因素和多因素 logistic 回归分析来确定 TAD 的危险因素。
BA 占弓部变异的 79.8%，是最常见的主动脉弓分支变异。BA 患者中 BAV 的发生率为 52.6%，正常弓部患者中 BAV 的发生率为 38.1%。在 185 例 BAV 亚组患者中，50 例有 BA，135 例有 NA。BA 和 NA 之间的 BAV 解剖表型、主动脉病变表型和瓣膜功能无显著差异。多因素分析显示，BAV 的存在和男性是 TAD 的危险因素。BA 在单因素或多因素分析中均不是 TAD 的危险因素。
BA 患者中 BAV 的比例明显高于 NA 患者，但 BAV 表型和主动脉病变与 BA 无关。BAV 是 TAD 的危险因素，而 BA 与 TAD 无关。
