Xiong Can, Tian Lin, Xiao Chunchun, Xue Zhenggang, Zhou Fangyao, Zhou Huang, Zhao Yafei, Chen Min, Wang Qiuping, Qu Yunteng, Hu Yidong, Wang Wenyu, Zhang Yan, Zhou Xiao, Wang Zhiyuan, Yin Peiqun, Mao Yu, Yu Zhen-Qiang, Cao Yueqiang, Duan Xuezhi, Zheng Lei, Wu Yuen
School of Chemistry and Environmental Engineering, Institute of Low-dimensional Materials Genome Initiative, Shenzhen University, Shenzhen 518060, China; School of Chemistry and Materials Science, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230026, China.
School of Chemistry and Materials Science, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230026, China.
Sci Bull (Beijing). 2020 Dec 30;65(24):2100-2106. doi: 10.1016/j.scib.2020.07.031. Epub 2020 Jul 25.
The development of high-performance glucose sensors is an urgent need, especially for diabetes mellitus diagnosis. However, the glucose monitoring is conventionally operated in an invasive finger-prick manner and their noninvasive alternatives largely suffered from the relatively poor sensitivity, selectivity, and stability, resulted from the lack of robust and efficient catalysts. In this paper, we design a concave shaped nitrogen-doped carbon framework embellished with single Co site catalyst (Co SSC) by selectively controlling the etching rate on different facet of carbon substrate, which is beneficial to the diffusion and contact of analyte. The Co SSC prompts a significant improvement in the sensitivity of the solution-gated graphene transistor (SGGT) devices, with three orders of magnitude better than those of SGGT devices without catalysts. Our findings expand the field of single site catalyst in the application of biosensors, diabetes diagnostics and personalized health-care monitoring.
高性能葡萄糖传感器的开发迫在眉睫，尤其是对于糖尿病的诊断。然而，传统的葡萄糖监测采用侵入性手指采血方式，其非侵入性替代方法大多因缺乏强大而高效的催化剂而在灵敏度、选择性和稳定性方面相对较差。在本文中，我们通过选择性地控制碳基底不同晶面的蚀刻速率，设计了一种装饰有单钴位点催化剂（Co SSC）的凹形氮掺杂碳框架，这有利于分析物的扩散和接触。Co SSC显著提高了溶液门控石墨烯晶体管（SGGT）器件的灵敏度，比没有催化剂的SGGT器件高出三个数量级。我们的发现扩展了单位点催化剂在生物传感器、糖尿病诊断和个性化医疗监测应用中的领域。
