Matsuki Goshi, Nakajima Takayoshi, Ichise Noriko, Nomura Kazunori, Fujikawa Masataka, Kasai Meidai, Okamoto Ryo, Ikuta Shinichi, Nakamoto Yoshihiko, Aihara Tsukasa, Kajimoto Noriko, Kakuno Ayako, Yanagi Hidenori, Yamanaka Naoki
Dept. of Surgery, Meiwa Hospital.
Gan To Kagaku Ryoho. 2022 Dec;49(13):1739-1741.
A 70-year-old woman was admitted to a local hospital because of anal pain during defecation. Anoscopy revealed an anal mass lesion, and the patient was referred to our hospital. Colonoscopy revealed an anal canal tumor with ulceration, and biopsy showed squamous cell carcinoma. The patient was treated with chemoradiotherapy(chemotherapy with capecitabine plus mitomycin C and 54 Gy radiation in the anal region)and achieved complete response. However, metastatic recurrence was detected in a lymph node in the hepatic hilar region. We administered an S-1/CDDP combination chemotherapy (5 courses). For 3 years and 5 months since the initial treatment, the patient survived with no signs of recurrence. We report a rare case of long-term survival with S-1/CDDP for distant metastasis of anal canal squamous cell carcinoma after chemoradiotherapy.
一名70岁女性因排便时肛门疼痛入住当地医院。肛门镜检查发现肛门有肿物病变，该患者被转诊至我院。结肠镜检查发现肛管肿瘤伴溃疡，活检显示为鳞状细胞癌。患者接受了放化疗（卡培他滨加丝裂霉素C化疗及肛门区域54 Gy放疗）并获得完全缓解。然而，在肝门区淋巴结检测到转移复发。我们给予S-1/顺铂联合化疗（5个疗程）。自初始治疗以来3年零5个月，患者存活且无复发迹象。我们报告了1例肛管鳞状细胞癌放化疗后远处转移经S-1/顺铂治疗长期存活的罕见病例。
