Department of Medical Biotechnology, Faculty of Paramedicine, Guilan University of Medical Sciences, Rasht, Iran.
Department of Biomedical Sciences, University of Lausanne, Rue Du Bugnon, Lausanne, Switzerland.
Anticancer Agents Med Chem. 2023;23(11):1253-1264. doi: 10.2174/1871520623666230202163112.
Glioblastoma multiforme (GBM) is an aggressive form of adult brain tumor that can arise from a low-grade astrocytoma. In recent decades, several new conventional therapies have been developed that have significantly improved the prognosis of patients with GBM. Nevertheless, most patients have a limited long-term response to these treatments and survive < 1 year. Therefore, innovative anti-cancer drugs that can be rapidly approved for patient use are urgently needed. One way to achieve accelerated approval is drug repositioning, extending the use of existing drugs for new therapeutic purposes, as it takes less time to validate their biological activity as well as their safety in preclinical models. In this review, a comprehensive analysis of the literature search was performed to list drugs with antiviral, antiparasitic, and antidepressant properties that may be effective in GBM and their putative anti-tumor mechanisms in GBM cells.
多形性胶质母细胞瘤（GBM）是一种侵袭性成人脑肿瘤，可起源于低级别星形细胞瘤。近几十年来，已经开发出了几种新的常规疗法，这显著改善了 GBM 患者的预后。然而，大多数患者对这些治疗的长期反应有限，生存时间<1 年。因此，迫切需要能够快速批准用于患者的创新抗癌药物。实现加速批准的一种方法是药物重定位，即将现有药物用于新的治疗目的，因为在临床前模型中验证其生物活性及其安全性所需的时间更少。在这篇综述中，对文献检索进行了全面分析，列出了具有抗病毒、抗寄生虫和抗抑郁特性的药物，这些药物可能对 GBM 有效，以及它们在 GBM 细胞中的潜在抗肿瘤机制。
