Zhang Ning, Zhang Quan, Nurmikko Arto
School of Engineering, Brown University, 184 Hope St, Providence, RI, 02912, USA.
Massachusetts General Hospital, Harvard Medical School, 13th Street, Charlestown, MA, 02129, USA.
Biomed Opt Express. 2022 Oct 18;13(11):5926-5936. doi: 10.1364/BOE.470724. eCollection 2022 Nov 1.
We demonstrate an ultra-high-density source-detector (SD) diffuse optical tomography system scalable to thousands of combinatorial SD pairs per cm of total voxel volume. We demonstrate the imaging of dynamic targets (including phantom arteries) with 100 um resolution at over 10 Hz frame rate within turbid media (> 60 MFP). Further, as a step toward a wearable mobile imager, we introduce monolithic mm-size dense semiconductor laser array chips as sources for potential unobtrusive epidermal tomographic use.
我们展示了一种超高密度源探测器（SD）漫射光学层析成像系统，该系统可扩展至每立方厘米总体素体积数千个组合式SD对。我们展示了在浑浊介质（>60个平均自由程）中以超过10 Hz的帧率对动态目标（包括模拟动脉）进行100微米分辨率的成像。此外，作为迈向可穿戴移动成像仪的一步，我们引入了毫米尺寸的单片密集半导体激光阵列芯片作为潜在的非侵入性表皮层析成像的光源。
