Leite João, Romano João, Lopes Virginia, Neves Miguel Mesquita, Gomes Miguel, Oliveira Luis
Department of Ophthalmology, Centro Hospitalar Universitário do Porto (CHUPorto), Porto, Portugal.
Department of Ophthalmology, Centro Hospitalar de Leiria, Leiria, Portugal.
Int Med Case Rep J. 2023 Jan 27;16:59-64. doi: 10.2147/IMCRJ.S392781. eCollection 2023.
spp are ubiquitous pigmented filamentous fungi that can cause opportunistic human infections. These molds can be found in healthy individuals and the most frequently observed clinical manifestations are skin infections, ocular mycosis, rhinosinusitis, among others. Immunosuppression (both local and systemic) as well as contact or trauma with contaminated matter are important risk and predisposing factors for ocular mycosis. Accurate diagnosis with microscopy and culture is crucial since infections by filamentous fungi are sight-threatening, and clinically indistinguishable from bacterial disease. In general terms, conventional antifungal drugs are effective.
We report a case of after ocular trauma with biological material in a 44-year-old man's functional single eye, which had a good clinical and functional evolution after topical therapy with voriconazole.
This case accounts the importance of thinking about other etiological diagnoses in infectious keratitis refractory to the established therapy and with a history of trauma with biological material.
暗色丝孢霉是普遍存在的色素沉着丝状真菌,可引起人类机会性感染。这些霉菌可在健康个体中发现,最常见的临床表现是皮肤感染、眼部真菌病、鼻-鼻窦炎等。免疫抑制(局部和全身)以及与污染物质的接触或创伤是眼部真菌病的重要风险和易感因素。由于丝状真菌感染会威胁视力,且在临床上与细菌性疾病难以区分,因此通过显微镜检查和培养进行准确诊断至关重要。一般来说,传统抗真菌药物是有效的。
我们报告一例44岁单眼有功能的男性眼部因生物材料外伤后发生的病例,该患者在使用伏立康唑局部治疗后临床和功能恢复良好。
该病例说明了对于既定治疗无效且有生物材料外伤史的感染性角膜炎,考虑其他病因诊断的重要性。