未活化烯烃的不对称生物环氧化反应

Asymmetric Bio-epoxidation of Unactivated Alkenes.

作者信息

Li Jiajing, Gu Wenjing, Wang Zhongqiang, Zhou Xiaojian, Chen Yongzheng

机构信息

Key Laboratoryof Biocatalysis and Chiral Drug Synthesis of Guizhou Province, Green Pharmaceuticals Engineering Research Center of Guizhou Province, Zunyi Medical University, 563000, Zunyi, P. R. China.

Key Laboratory of Basic Pharmacology of Ministry of Education, Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, 563000, Zunyi, P. R. China.

出版信息

Chembiochem. 2023 Apr 3;24(7):e202200719. doi: 10.1002/cbic.202200719. Epub 2023 Mar 10.

DOI:10.1002/cbic.202200719

PMID:36734180

Abstract

Optically active epoxides play important roles in pharmaceutical, agricultural and fine chemical syntheses. There are many chiral medications with pharmacodynamic activity in nature that can be synthesized by chiral epoxides. In recent years, researchers have developed a variety of biocatalysts for the asymmetric epoxidation of alkenes, which use oxygen or hydrogen peroxide as eco-friendly and low-cost oxidants, to provide better chemo-, regio- and stereoselectivity under moderate reaction conditions. In this paper, the advances, opportunities and challenges of the asymmetric epoxidation of unactive alkenes by biocatalyst are reviewed.

摘要

光学活性环氧化合物在药物、农业和精细化学合成中发挥着重要作用。自然界中有许多具有药效活性的手性药物可通过手性环氧化合物合成。近年来，研究人员开发了多种用于烯烃不对称环氧化的生物催化剂，这些催化剂使用氧气或过氧化氢作为环境友好且低成本的氧化剂，能在温和反应条件下提供更好的化学、区域和立体选择性。本文综述了生物催化剂催化非活性烯烃不对称环氧化的研究进展、机遇和挑战。