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百会穴艾灸联合针刺治疗颈性眩晕的Meta分析与试验序贯分析

[Moxibustion at Baihui combined with acupuncture for cervical vertigo: a Meta-analysis and trial sequential analysis].

作者信息

Mai Wei, Bu Xian-Zhong, Miao Fu-Rui, Rui Jing-Lin, Huang Li-Lin, Zhao Xiao-Jun, Fan Yu-Shan

机构信息

Department of Traditional Chinese Medicine, Guangxi Medical University Cancer Hospital, Nanning 530021, China; Guangxi University of Chinese Medicine, Nanning 530001.

Guangxi University of Chinese Medicine, Nanning 530001.

出版信息

Zhen Ci Yan Jiu. 2023 Jan 25;48(1):95-101. doi: 10.13702/j.1000-0607.20211054.

Abstract

OBJECTIVE

To evaluate the efficacy and safety of moxibustion at Baihui (CV20) combined with acupuncture in treatment of cervical vertigo.

METHODS

From the databases, such as CNKI, VIP, WanFang, CBM, PubMed, Cochrane Library and Embase, the studies of randomized controlled trials (RCTs) on moxibustion at CV20 combined with acupuncture for cervical vertigo were searched from inception to September 15, 2021. The Cochrane risk of bias assessment tool was utilized to evaluate the quality of the included literature. Using RevMan5.3, Stata12.0 and TSA0.9.5.0 10 Beta software, the Meta-analysis and trial sequential analysis (TSA) were performed.

RESULTS

Seventeen RCTs with 1 232 patients were included. Meta-analysis showed that in the trial group (moxibustion at CV20 combined with acupuncture), the total effective rate (=1.17, 95%[1.12, 1.22], <0.000 1), the curative and remarkably-effective rate (=1.28,95%[1.20,1.36],<0.000 1) and the score of cervical vertigo (=2.88, 95%[1.87, 3.89], <0.000 1) were all better when compared with the control group (simple acupuncture or electroacupuncture group). The results of trial sequential analysis indicated that for the cumulative Z-score of each RCT, the Z-curve crossed the conventional test boundary and TSA boundary, which further confirmed the clinical efficacy of moxibustion at CV20 combined with acupuncture on cervical vertigo.

CONCLUSION

The clinical efficacy of moxibustion at CV20 combined with acupuncture is determined in treatment of cervical vertigo.

摘要

目的

评价百会穴(CV20)艾灸联合针刺治疗颈性眩晕的疗效及安全性。

方法

通过检索中国知网(CNKI)、维普(VIP)、万方、中国生物医学文献数据库(CBM)、PubMed、Cochrane图书馆和Embase等数据库,收集自建库至2021年9月15日关于百会穴艾灸联合针刺治疗颈性眩晕的随机对照试验(RCT)研究。采用Cochrane偏倚风险评估工具评价纳入文献的质量。使用RevMan5.3、Stata12.0和TSA0.9.5.0 10 Beta软件进行Meta分析和试验序贯分析(TSA)。

结果

纳入17项RCT,共1 232例患者。Meta分析显示,试验组(百会穴艾灸联合针刺)的总有效率(比值比=1.17,95%可信区间[1.12,1.22],P<0.000 1)、痊愈显效率(比值比=1.28,95%可信区间[1.20,1.36],P<0.000 1)和颈性眩晕评分(均数差=2.88,95%可信区间[1.87,3.89],P<0.000 1)均优于对照组(单纯针刺或电针组)。试验序贯分析结果表明,各RCT的累积Z值曲线越过传统检验界值和TSA界值,进一步证实了百会穴艾灸联合针刺治疗颈性眩晕的临床疗效。

结论

百会穴艾灸联合针刺治疗颈性眩晕具有确切的临床疗效。

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