Chitkara College of Pharmacy, Chitkara University, Punjab 140401, India.
Department of Pharmacy, G.D. Goenka University, Sohna Road, Gurugram 122103, India.
Crit Rev Ther Drug Carrier Syst. 2023;40(2):1-41. doi: 10.1615/CritRevTherDrugCarrierSyst.2022038398.
Anti-cancer drugs are mostly limited in their use due to poor physicochemical and biopharmaceutical properties. Their lower solubility is the most common hurdle limiting their use upto their potential. In the recent years, the cyclodextrin (CD) complexation have emerged as existing approach to overcome the problem of poor solubility. CD-based nano-technological approaches are safe, stable and showed well in vivo tolerance and greater payload for encapsulation of hydrophobic drugs for the targeted delivery. They are generally chosen due to their ability to get self-assembled to form liposomes, nanoparticles, micelles and nano-sponges etc. This review paper describes a birds-eye view of the various CD-based nano-technological approaches applied for the delivery of anti-cancer moieties to the desired target such as CD based liposomes, niosomes, niosoponges, micelles, nanoparticles, monoclonal antibody, magnetic nanoparticles, small interfering RNA, nanorods, miscellaneous formulation of anti-cancer drugs containing CD. Moreover, the author also summarizes the various shortcomings of such a system and their way ahead.
抗癌药物由于其较差的物理化学和生物药剂学性质，其应用受到限制。它们较低的溶解度是限制其发挥潜力的最常见障碍。近年来，环糊精（CD）络合已成为克服溶解度差问题的现有方法。基于 CD 的纳米技术方法安全、稳定，体内耐受性良好，对封装疏水性药物的载药量更大，可实现靶向递送。由于其能够自组装形成脂质体、纳米粒、胶束和纳米海绵等，因此通常选择基于 CD 的纳米技术方法。本文综述了各种基于 CD 的纳米技术方法在将抗癌药物递送到所需靶标（如基于 CD 的脂质体、非离子型脂质体、非离子型海绵、胶束、纳米粒、单克隆抗体、磁性纳米粒、小干扰 RNA、纳米棒、含 CD 的抗癌药物的各种制剂）中的应用。此外，作者还总结了此类系统的各种缺点及其未来的发展方向。
