Feng Lanni, Wei Ruting, Wu Jiali, Chen Xinmei, Wen Yan, Chen Jianming
Department of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China.
Shanghai WeiEr Lab, Shanghai, 201707, China.
AAPS PharmSciTech. 2024 Dec 5;26(1):3. doi: 10.1208/s12249-024-02999-0.
Cyclodextrin complexes have been widely used in pharmaceutical applications, but disadvantages such as the rapid clearance of cyclodextrins from the blood stream after in vivo administration or their replacement by other molecules in the biological medium with higher luminal affinity for cyclodextrins limit the application of cyclodextrins as drug carriers. Liposome-encapsulated hydrophobic drugs have low and unstable drug loading rates. Drug-in-CD-in-liposome (DCL), which encapsulate cyclodextrin inclusion complexes into liposomes, combine the advantages of both delivery systems, can effectively avoid the leakage and rapid release of lipophilic drugs in the lipid bilayer, and help to maintain the integrity of liposomes. This paper focuses on the preparation method, characterization and application of DCL, with a view to providing methods and references for the research and application of DCL technology.
环糊精复合物已广泛应用于制药领域，但存在一些缺点，如体内给药后环糊精从血流中快速清除，或在生物介质中被对环糊精具有更高腔亲和力的其他分子取代，这限制了环糊精作为药物载体的应用。脂质体包裹的疏水性药物载药率低且不稳定。将环糊精包合物包裹在脂质体中的药物-环糊精-脂质体（DCL）结合了两种给药系统的优点，能有效避免亲脂性药物在脂质双层中的泄漏和快速释放，并有助于维持脂质体的完整性。本文重点介绍了DCL的制备方法、表征及应用，以期为DCL技术的研究与应用提供方法和参考。
