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PI3P regulates multiple stages of membrane fusion.
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Sec18 binds the tethering/SM complex HOPS to engage the Qc-SNARE for membrane fusion.
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3
Sec17 (α-SNAP) and Sec18 (NSF) restrict membrane fusion to R-SNAREs, Q-SNAREs, and SM proteins from identical compartments.
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Sec17 can trigger fusion of trans-SNARE paired membranes without Sec18.
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Asymmetric Rab activation of vacuolar HOPS to catalyze SNARE complex assembly.
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引用本文的文献

2
MARCKS Effector Domain, a reversible lipid ligand, illuminates late stages of membrane fusion.
Mol Biol Cell. 2023 Nov 1;34(12):ar123. doi: 10.1091/mbc.E23-06-0228. Epub 2023 Sep 6.
3
Efficient fusion requires a membrane anchor on the vacuolar Qa-SNARE.
Mol Biol Cell. 2023 Aug 1;34(9):ar88. doi: 10.1091/mbc.E23-02-0052. Epub 2023 Jun 14.

本文引用的文献

1
Sec18 supports membrane fusion by promoting Sec17 membrane association.
Mol Biol Cell. 2022 Nov 1;33(13):ar127. doi: 10.1091/mbc.E22-07-0274. Epub 2022 Sep 14.
2
Fusion with wild-type SNARE domains is controlled by juxtamembrane domains, transmembrane anchors, and Sec17.
Mol Biol Cell. 2022 May 1;33(5):ar38. doi: 10.1091/mbc.E21-11-0583. Epub 2022 Feb 16.
5
Asymmetric Rab activation of vacuolar HOPS to catalyze SNARE complex assembly.
Mol Biol Cell. 2020 May 1;31(10):1060-1068. doi: 10.1091/mbc.E20-01-0019. Epub 2020 Mar 11.
7
Tethering guides fusion-competent -SNARE assembly.
Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):13952-13957. doi: 10.1073/pnas.1907640116. Epub 2019 Jun 24.
8
Munc18-1 catalyzes neuronal SNARE assembly by templating SNARE association.
Elife. 2018 Dec 12;7:e41771. doi: 10.7554/eLife.41771.
10
HOPS catalyzes the interdependent assembly of each vacuolar SNARE into a SNARE complex.
Mol Biol Cell. 2017 Apr 1;28(7):975-983. doi: 10.1091/mbc.E16-10-0743. Epub 2017 Feb 1.

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