评估咖啡饮用与慢性疼痛、抑郁和焦虑之间关系的关联。

Assessing the association of coffee consumption on the relationship of chronic pain with depression and anxiety.

机构信息

Key Laboratory of Trace Elements and Endemic Diseases, Collaborative Innovation Center of Endemic Disease and Health Promotion for Silk Road Region, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, People's Republic of China.

出版信息

Nutr Neurosci. 2024 Mar;27(3):196-206. doi: 10.1080/1028415X.2023.2175412. Epub 2023 Feb 3.

DOI:10.1080/1028415X.2023.2175412

PMID:36735653

Abstract

BACKGROUND

A bidirectional relationship between chronic pain (CP) and mental disorders has been reported, and coffee was believed to be associated with both. However, the association of coffee in this bidirectional relationship remains unclear. We aim to analyze the association of coffee consumption on the relationship of CP with depression and anxiety.

METHODS

A total of 376,813 participants from UK Biobank were included. We collected data on anxiety, depression and CP from objects of our study population. The association of coffee consumption on the relationship of CP with depression and anxiety was assessed through logistic/linear regression models. Moreover, seemingly unrelated estimation test (SUEST) was used to compare whether the coefficients differed in two different groups.

RESULTS

We observed significant associations of coffee consumption in the interaction of CP with depression and anxiety, such as the association of multisite chronic pain (MCP) on self-reported depression (= 0.421, = 0.488, = 0.001), and the association of MCP on generalized anxiety disorder-7 (GAD-7) scores (= 0.561, = 0.678, = 0.004) were significantly different between coffee drinking and non-coffee drinking groups. Furthermore, in analysis stratified by gender, we found headache (= 0.392, = 0.214, = 0.022) and hip pain (= 0.480, = 0.191, = 0.021) had significant associations with self-reported depression between males and females groups in coffee drinkers.

CONCLUSIONS

Our results suggested that coffee consumption has a significant association on the relationship of CP with depression and anxiety.

摘要

背景

慢性疼痛（CP）和精神障碍之间存在双向关系，并且咖啡被认为与两者都有关。然而，咖啡在这种双向关系中的作用尚不清楚。我们旨在分析咖啡消费与 CP 与抑郁和焦虑之间关系的关联。

方法

共纳入英国生物库 376813 名参与者。我们从研究对象中收集了有关焦虑、抑郁和 CP 的数据。通过逻辑/线性回归模型评估了咖啡消费与 CP 与抑郁和焦虑之间关系的关联。此外，还使用似乎不相关的估计检验（SUEST）来比较两组之间的系数是否存在差异。

结果

我们观察到咖啡消费在 CP 与抑郁和焦虑的相互作用中的显著关联，例如多部位慢性疼痛（MCP）与自我报告的抑郁之间的关联（=0.421，=0.488，=0.001），以及 MCP 与广泛性焦虑障碍-7（GAD-7）评分之间的关联（=0.561，=0.678，=0.004）在喝咖啡和不喝咖啡的人群之间存在显著差异。此外，在按性别分层的分析中，我们发现头痛（=0.392，=0.214，=0.022）和髋痛（=0.480，=0.191，=0.021）在喝咖啡的男性和女性组之间与自我报告的抑郁有显著关联。