Ceriello Antonio, Lalic Nebjosa, Montanya Eduard, Valensi Paul, Khunti Kamlesh, Hummel Michael, Schnell Oliver
IRCCS Multimedica, Via Gaudenzio Fantolio, 16/15, 20138 Milan, Italy.
Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia and Faculty of Medicine University of Belgrade, Dr Subotića 13, 11000 Belgrade, Serbia.
J Diabetes Complications. 2023 Mar;37(3):108410. doi: 10.1016/j.jdiacomp.2023.108410. Epub 2023 Jan 27.
AIMS: We used N-terminal pro-B-type natriuretic peptide (NT-proBNP) point-of-care testing (POCT) for heart failure risk stratification of individuals with type 2 diabetes for >10 years and hypertension. METHODS: Overall 259 participants aged 50 years or older with type 2 diabetes (duration of >10 years), hypertension, and no overt cardiovascular disease (CVD) were recruited at two study centers. Patients' data were acquired and NT-proBNP levels were measured using the CARDIAC proBNP+ test (Roche) and the cobas h232 instrument (Roche). Participants were clustered into two groups according to their NT-proBNP concentration value: with NT-proBNP <125 pg/ml and with NT-proBNP ≥125 pg/ml. RESULTS: Mean age of the participants was 66.1 ± 9.2 years, 55.2 % were female, 60.6 % (n = 157) had a NT-proBNP <125 pg/ml and 39.4 % (n = 102 ≥ 125 pg/ml). Differences were observed among those with low and high NT-proBNP in mean age (63.4 ± 8.8 years vs. 70.1 ± 8.2 years, p < 0.001), diabetes duration (15.4 ± 5.9 years vs. 17.9 ± 7.3 years, p = 0.003), and estimated glomerular filtration rate (eGFR) (86 ± 16 ml/min/1.73 m vs. 76 ± 20 ml/min/1.73 m, p < 0.001). CONCLUSIONS: NT-proBNP POCT is practical and can be pragmatically targeted for screening people with type 2 diabetes and hypertension for heart failure risk stratification in routine clinical practice.
目的：我们使用N末端B型利钠肽原（NT-proBNP）即时检测（POCT）对患有2型糖尿病超过10年且患有高血压的个体进行心力衰竭风险分层。 方法：在两个研究中心招募了259名年龄在50岁及以上、患有2型糖尿病（病程超过10年）、高血压且无明显心血管疾病（CVD）的参与者。收集患者数据，并使用CARDIAC proBNP+检测（罗氏公司）和cobas h232仪器（罗氏公司）测量NT-proBNP水平。参与者根据其NT-proBNP浓度值分为两组：NT-proBNP<125 pg/ml组和NT-proBNP≥125 pg/ml组。 结果：参与者的平均年龄为66.1±9.2岁，55.2%为女性，60.6%（n = 157）的NT-proBNP<125 pg/ml，39.4%（n = 102≥125 pg/ml）。NT-proBNP低水平和高水平者在平均年龄（63.4±8.8岁 vs. 70.1±8.2岁，p<0.001）、糖尿病病程（15.4±5.9年 vs. 17.9±7.3年，p = 0.003）和估算肾小球滤过率（eGFR）（86±16 ml/min/1.73 m² vs. 76±20 ml/min/1.73 m²，p<0.001）方面存在差异。 结论：NT-proBNP POCT切实可行，在常规临床实践中可实际用于筛查2型糖尿病和高血压患者的心力衰竭风险分层。
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