迁移介导成熟：用于增强神经分化的合成底物。
Mobility mediates maturation: Synthetic substrates to enhance neural differentiation.
作者信息
Roth Julien G, Huang Michelle S, Heilshorn Sarah C
机构信息
Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA; Stanford Brain Organogenesis, Wu Tsai Neurosciences Institute & Bio-X, Stanford University, Stanford, CA, USA.
Department of Chemical Engineering, Stanford University, Stanford, CA, USA.
出版信息
Cell Stem Cell. 2023 Feb 2;30(2):115-117. doi: 10.1016/j.stem.2023.01.001.
The maturation of human induced pluripotent stem cell (hiPSC)-derived neurons in 2D is dependent upon cell attachment, spreading, and pathfinding across a biomaterial substrate. In this issue of Cell Stem Cell, Álvarez et al. demonstrate that highly mobile supramolecular scaffolds facilitate long-term hiPSC-derived motor neuron culture, increase maturation-related phenotypes, and recapitulate disease-relevant pathologies.
人诱导多能干细胞（hiPSC）来源的神经元在二维环境中的成熟依赖于细胞在生物材料基质上的附着、铺展和路径寻找。在本期《细胞·干细胞》中，阿尔瓦雷斯等人证明，高度可移动的超分子支架有助于长期培养hiPSC来源的运动神经元，增加与成熟相关的表型，并重现与疾病相关的病理状态。
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