促进更安全细胞疗法的 HLA 纯合子单倍型库资源。
An HLA-homozygous haplobank resource to promote safer cell therapies.
机构信息
International Stem Cell Banking Initiative, 2 High Street, Barley SG88HZ, UK; National Stem Cell Resource Centre, Institute of Zoology, Chinese Academy of Sciences, Beijing 100190, China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China; SSCBio Ltd, 2 High Street, Barley, Hertfordshire SG88HZ, UK.
出版信息
Cell Stem Cell. 2023 Feb 2;30(2):118-119. doi: 10.1016/j.stem.2023.01.003.
The generation of donor-derived induced pluripotent stem cells (iPSCs) for allogeneic transplantation is a major challenge in regenerative medicine. Yoshida et al. now report on the establishment of an HLA-homozygous haplobank of iPSCs that covers approximately 40% of the Japanese population and describe quality and safety considerations for manufacturing.
异体移植来源的诱导多能干细胞（iPSC）的生成是再生医学的一大挑战。Yoshida 等人现报道建立了一个涵盖约 40%日本人口的 HLA 纯合单倍型 iPSC 库，并描述了其制造的质量和安全性考虑因素。
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