Rupprecht R, Barocka A, Jecht E, Noder M, Pichl J, Schwarz W
Department of Psychiatry, University of Erlangen-Nürnberg, West Germany.
Acta Psychiatr Scand. 1987 Aug;76(2):139-43. doi: 10.1111/j.1600-0447.1987.tb02876.x.
Pre- and post-dexamethasone prolactin and cortisol levels of 40 endogenous and non-endogenous depressive patients and of 20 controls were studied. Dexamethasone had a suppressive effect on prolactin levels, which was expressed more in normal controls and in non-endogenous depressive patients than in endogenous depression. A "prolactin suppression test" by dexamethasone was constructed and provided comparable results to the usual DST. However, it failed to be a specific marker for endogenous depression. There are close relationships between various endocrine axes, which might be altered in depression.
对40名内源性和非内源性抑郁症患者以及20名对照者在服用地塞米松前后的催乳素和皮质醇水平进行了研究。地塞米松对催乳素水平有抑制作用，在正常对照者和非内源性抑郁症患者中比在内源性抑郁症患者中表现得更明显。构建了地塞米松的“催乳素抑制试验”，其结果与常规地塞米松抑制试验相当。然而，它未能成为内源性抑郁症的特异性标志物。各种内分泌轴之间存在密切关系，这些关系在抑郁症中可能会发生改变。
