Joyce P R, Donald R A, Nicholls M G, Livesey J H, Abbott R M
Psychol Med. 1986 Aug;16(3):531-40. doi: 10.1017/s0033291700010291.
Twenty patients with a major depressive disorder and 20 control subjects were subjected to a 1 mg dexamethasone suppression test (DST) and a challenge with intravenous (IV) methylphenidate (MP)(0.3 mg/kg). None of the controls, but 9 depressives, were DST non-suppressors. Among the depressives there were correlations between DST-cortisol and baseline (4 p.m.) levels of cortisol, growth hormone, prolactin and adrenaline. Compared with the controls the depressives had a decreased cortisol response and an enhanced adrenaline response to the MP challenge. The decreased cortisol response was not related to either DST-cortisol or baseline cortisol, but was correlated with the mood response to MP.
20名重度抑郁症患者和20名对照受试者接受了1毫克地塞米松抑制试验（DST）以及静脉注射（IV）哌醋甲酯（MP）（0.3毫克/千克）的激发试验。对照组中无人为DST非抑制者，但抑郁症患者中有9人为DST非抑制者。在抑郁症患者中，DST-皮质醇与皮质醇、生长激素、催乳素和肾上腺素的基线（下午4点）水平之间存在相关性。与对照组相比，抑郁症患者对MP激发试验的皮质醇反应降低，肾上腺素反应增强。皮质醇反应降低与DST-皮质醇或基线皮质醇均无关，但与对MP的情绪反应相关。
