Investigador por México-CONACYT, Centro de Investigaciones Biomédicas de Occidente, IMSS, Guadalajara, Jalisco, México.
Departamento de Medicina y Ciencias de la Salud, División de Ciencias Biológicas y de la Salud, Universidad de Sonora, Hermosillo, México.
Prim Care Diabetes. 2023 Apr;17(2):113-118. doi: 10.1016/j.pcd.2023.01.008. Epub 2023 Jan 30.
Type 2 Diabetes Mellitus is known to be linked to malfunctioning antiviral defense; however, its association with the severity of monkeypox is poorly understood. In this review, we discuss key immunological mechanisms in the antiviral response affected by poor glucose control that could impact the susceptibility and severity of monkeypox infection, leading to a heightened emphasis on the use of the available antidiabetic drugs.
We searched PubMed and Google scholar for articles published from January 1985 to August 2022. No criteria for publication data were set, and all articles in English were included.
Currently, there are no studies about the risk or consequences of monkeypox infection in the diabetic population. A high incidence of diabetes is reported in countries such as China, India, Pakistan, EUA, Indonesia, Brazil, Mexico, Bangladesh, Japan, and Egypt, where unfortunately imported cases of monkeypox have been reported and the infection continues to spread.
High incidence of diabetes together with the cessation of smallpox vaccination has left large numbers of the human population unprotected against monkeypox. The best option for the population remains confined to the prevention of infection as well as the use of hypoglycemic agents that have also been shown to improve immune mechanisms associated with viral protection.
已知 2 型糖尿病与抗病毒防御功能障碍有关；然而，其与猴痘严重程度的关系尚不清楚。在这篇综述中，我们讨论了受血糖控制不佳影响的抗病毒反应中的关键免疫机制，这些机制可能会影响猴痘感染的易感性和严重程度，从而更加重视使用现有的抗糖尿病药物。
我们在 PubMed 和 Google Scholar 上搜索了 1985 年 1 月至 2022 年 8 月发表的文章。未设置出版数据标准，所有英文文章均被纳入。
目前，没有关于糖尿病患者感染猴痘的风险或后果的研究。中国、印度、巴基斯坦、欧盟、印度尼西亚、巴西、墨西哥、孟加拉国、日本和埃及等国家报告了较高的糖尿病发病率，不幸的是，这些国家报告了输入性猴痘病例，感染仍在继续蔓延。
糖尿病发病率高，加上天花疫苗接种的停止，使得大量人群无法预防猴痘。对于人类来说，最好的选择仍然是预防感染，以及使用已被证明能改善与病毒保护相关的免疫机制的降糖药物。
