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猴痘再现:预防与管理。

Reemergence of monkeypox: prevention and management.

机构信息

Department of Pharmaceutical Chemistry & Quality Assurance, St. John Institute of Pharmacy and Research, Palghar 401404, India.

Department of Pharmaceutical Chemistry & Quality Assurance, SVKM's Dr. Bhanuben Nanavati College of Pharmacy, Mumbai 400056, India.

出版信息

Expert Rev Anti Infect Ther. 2022 Nov;20(11):1425-1433. doi: 10.1080/14787210.2022.2128763. Epub 2022 Sep 30.

Abstract

INTRODUCTION

The reemergence of monkeypox virus in the twenty-first century, calls for an urgency in its control and preventive measures. There is a long-standing concern that the reemergence of monkeypox across countries could lead to another epidemic like the COVID-19 pandemic. Understanding the disease ecology, preventing its transmission could help curbing its spread. The established treatment protocols along with development of new antiviral agents and vaccines could play a pivotal role in controlling its transmission.

AREAS COVERED

In this review, we summarize the different modes of transmission of this disease, the associated symptoms, the standard protocol of treatment, the available vaccines and use of alternative treatments. We have collated recent research on novel entities that could potentially treat monkeypox infection.

EXPERT OPINION

The One Health approach fostered by the World Health Organization (WHO) for emergent and reemerging zoonotic diseases has to be implemented with a view to curb their transmission. The growing global population and increased inter-country travel has led to rapid spread of transmissible pathogens. Stigmatization, associated with lack of knowledge can be prevented by enhancing awareness campaigns. Vaccines need to be administered to high-risk individuals, and drug discovery efforts need to be intensified to combat such diseases.

摘要

简介

在 21 世纪,猴痘病毒再次出现,这就要求我们紧急控制和采取预防措施。人们长期以来一直担心,猴痘在各国的再次出现可能会导致另一场像 COVID-19 大流行这样的疫情。了解疾病的生态,防止其传播有助于控制其蔓延。既定的治疗方案,以及新的抗病毒药物和疫苗的开发,可以在控制其传播方面发挥关键作用。

涵盖领域

在这篇综述中,我们总结了这种疾病的不同传播方式、相关症状、标准治疗方案、可用的疫苗和替代治疗方法的使用。我们汇集了最近关于可能治疗猴痘感染的新型实体的研究。

专家意见

世界卫生组织(世卫组织)为新发和再现的人畜共患病实施的“同一健康”方法必须加以实施,以遏制其传播。全球人口的增长和国家间旅行的增加导致了可传播病原体的迅速传播。通过加强宣传活动,可以防止与知识缺乏有关的污名化。需要向高风险人群接种疫苗,需要加强药物发现工作,以防治此类疾病。

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