Fujicco Co., Ltd., 6-13-4 Minatojima-Nakamachi, Chuo-Ku, Kobe, Hyogo, 650-8558, Japan.
Sugi Pharmacy Co., Ltd., 62-1, Shin'e, Yokone-Machi, Obu, Aichi, 474-0011, Japan.
Sci Rep. 2023 Feb 3;13(1):1993. doi: 10.1038/s41598-023-29258-9.
Deglutition aid foods are used to help patients with dysphagia take oral medications. Yoghurt is occasionally used to help swallow medications; however, its influence on pharmacokinetics is poorly understood. Yoghurt made with Lactococcus cremoris subsp. cremoris FC has a characteristic viscous texture that facilitates bolus formation and deglutition due to its metabolite exopolysaccharide. We assessed yoghurt prepared with L. cremoris FC as a food deglutition aid. We performed a dissolution test using famotidine powder mixed with yoghurt and a food thickener. Famotidine dissolution rates without deglutition-assisting foods and with yoghurt or food thickener were 102.3 ± 1.7, 85.7 ± 4.6, and 46.4 ± 1.1% after 15 min, respectively. Next, we orally administered famotidine powder with water, yoghurt, and food thickener to rats and measured plasma famotidine levels. We observed no significant differences between all test groups. The T of famotidine mixed with a food thickener was significantly lower than that with yoghurt. These results suggest that yoghurt with L. cremoris FC did not remarkably affect the dissolution and pharmacokinetic profiles of famotidine powder. Thus, the administration of famotidine with yoghurt might be a suitable alternative to powder administration as a deglutition aid for patients.
吞咽辅助食品用于帮助吞咽困难的患者口服药物。酸奶偶尔用于帮助吞咽药物；然而，其对药代动力学的影响知之甚少。用乳球菌乳脂亚种制成的酸奶。 cremoris FC 具有特征性的粘性质地，由于其代谢产物胞外多糖，有利于形成和吞咽食团。我们评估了用 L. cremoris FC 制成的酸奶作为吞咽辅助食品。我们使用含有法莫替丁粉末的酸奶和食品增稠剂进行了溶解试验。在 15 分钟后，没有吞咽辅助食品的法莫替丁粉末的溶解率分别为 102.3±1.7%、85.7±4.6%和 46.4±1.1%，而添加酸奶或食品增稠剂后则分别为 85.7±4.6%和 46.4±1.1%。接下来，我们给大鼠口服用水、酸奶和食品增稠剂混合的法莫替丁粉末，并测量血浆中法莫替丁的水平。我们观察到所有测试组之间没有显著差异。与酸奶相比，法莫替丁与食品增稠剂混合的 T 明显更低。这些结果表明，含有 L. cremoris FC 的酸奶并没有显著影响法莫替丁粉末的溶解和药代动力学特征。因此，用酸奶给药可能是替代粉末给药作为吞咽困难患者的吞咽辅助剂的一种合适选择。
